摄氧量效率斜率：一项次最大测试评估工具，可提供帕金森病患者的心肺储备数据。
Oxygen uptake efficiency slope: A submaximal test evaluation tool that provides cardiopulmonary reserve data in individuals with Parkinson's disease.
机构信息
Cardiopulmonary Physiotherapy Laboratory, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
Applied Neuroscience Laboratory, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
出版信息
Braz J Phys Ther. 2021 Sep-Oct;25(5):641-647. doi: 10.1016/j.bjpt.2021.04.008. Epub 2021 May 3.
BACKGROUND
Oxygen uptake efficiency slope (OUES) is a method for investigating cardiorespiratory fitness and is proposed as an alternative to overcome the limitations of traditional measures such as peak oxygen consumption (VO) for patients who do not achieve a maximum response, such as in Parkinson's disease (PD).
OBJECTIVE
To assess the performance of individuals with PD during the six-minute walk test (6MWT) using the OUES.
METHODS
This is an observational cross-sectional study including 12 individuals with PD and 12 healthy controls. Participants performed the 6MWT along with an analysis of exhaled gas kinetics. The OUES was determined from the last 16 s of the walk test. Multiple linear regression analyses were computed to explore associations between the independent (OUES) and the dependent variables (VO) controlled by group.
RESULTS
The OUES was associated to VO on the 6MWT (β=0.24, p<0.01) in individuals with PD. The PD group had low performance on the 6MWT with a shorter distance walked (mean difference: -113.1 m; 95% CI: -203.2, -59.1) and worse cardiopulmonary condition with lower OUES values (mean difference: -0.52 [l/minO]/[l/minVE]; 95% CI: -0.83, -0.21) found in this same group.
CONCLUSIONS
Our results suggest that OUES is related to VO during the 6MWT, and therefore it could be used as a submaximal test evaluation tool which provides cardiopulmonary reserve data in individuals with PD.
背景
摄氧量效率斜率（OUES）是一种用于评估心肺功能的方法，它被提议作为一种替代传统峰值摄氧量（VO）的方法，用于那些无法达到最大反应的患者，例如帕金森病（PD）患者。
目的
使用 OUES 评估 PD 患者在六分钟步行测试（6MWT）中的表现。
方法
这是一项观察性横断面研究，纳入了 12 名 PD 患者和 12 名健康对照者。参与者在进行 6MWT 的同时进行呼气动力学分析。OUES 是从步行测试的最后 16 秒确定的。进行了多元线性回归分析，以探索独立变量（OUES）和受组控制的因变量（VO）之间的关联。
结果
OUES 与 PD 患者 6MWT 中的 VO 相关（β=0.24，p<0.01）。PD 组在 6MWT 中的表现较差，行走距离较短（平均差异：-113.1 m；95%CI：-203.2，-59.1），心肺状况较差，OUES 值较低（平均差异：-0.52 [l/minO]/[l/minVE]；95%CI：-0.83，-0.21）。
结论
我们的结果表明，OUES 与 6MWT 期间的 VO 相关，因此它可以用作次最大测试评估工具，为 PD 患者提供心肺储备数据。
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