摄氧效率斜率：一种从递增运动期间摄氧量与分钟通气量之间的关系得出的心肺功能储备新指标。

Oxygen uptake efficiency slope: a new index of cardiorespiratory functional reserve derived from the relation between oxygen uptake and minute ventilation during incremental exercise.

作者信息

Baba R, Nagashima M, Goto M, Nagano Y, Yokota M, Tauchi N, Nishibata K

机构信息

Department of Pediatrics, Nagoya University School of Medicine, Japan.

出版信息

J Am Coll Cardiol. 1996 Nov 15;28(6):1567-72. doi: 10.1016/s0735-1097(96)00412-3.

DOI:10.1016/s0735-1097(96)00412-3

PMID:8917273

Abstract

OBJECTIVES

We investigated the usefulness of a new variable, oxygen uptake efficiency slope (OUES), as a submaximal measure of cardiorespiratory functional reserve. The OUES is derived from the relation between oxygen uptake (Vo2 [ml/min]) and minute ventilation (VE [liters/min]) during incremental exercise and is determined by VO2 = a log VE + b, where a = OUES, which shows the effectiveness of Vo2.

BACKGROUND

Maximal oxygen uptake (VO2max) is effort dependent. There is no standard submaximal measurement of cardiorespiratory reserve that provides generally acceptable results.

METHODS

Exercise tests, following a standard Bruce protocol, were performed on a treadmill by 108 patients with heart disease and 36 normal volunteers. Expired gas was continuously analyzed. The OUES was calculated from data of the first 75%, 90% and 100% of exercise duration. We also determined the following submaximal variables: the ventilatory anaerobic threshold (VAT), the slope of the regression line of the minute ventilation-carbon dioxide production relation (VE-VCO2 slope) and the extrapolated maximal oxygen consumption (EMOC). We analyzed the relation of OUES and other submaximal variables against VO2max and examined the effects of submaximal exercise on OUES.

RESULTS

The correlation coefficient of the logarithmic curve-fitting model was 0.978 +/- 0.016 (mean +/- SD). The OUES and VO2max had a significant correlation (r = 0.941, p < 0.0001). The correlation between VO2max and OUES was stronger than that between VO2max and VAT, the VE-VCO2 slope or EMOC. The OUES values for 100% and 90% of exercise were not different from each other (at an alpha value of 0.05 and treatment effect of 170, the power of the test [1-beta] was 0.90); OUES for 75% of exercise was slightly lower (3.5%).

CONCLUSIONS

Our results suggest that OUES may provide an objective, effort-independent estimation of cardiorespiratory functional reserve that is related both to pulmonary dead space and to metabolic acidosis.

摘要

目的

我们研究了一个新变量——摄氧效率斜率（OUES）作为心肺功能储备次最大量度的有用性。OUES源自递增运动期间摄氧量（Vo2[毫升/分钟]）与分钟通气量（VE[升/分钟]）之间的关系，由VO2 = a log VE + b确定，其中a = OUES，它显示了Vo2的有效性。

背景

最大摄氧量（VO2max）取决于运动强度。目前尚无一种能提供普遍可接受结果的标准化心肺储备次最大量度方法。

方法

按照标准布鲁斯方案，对108例心脏病患者和36名正常志愿者在跑步机上进行运动试验。持续分析呼出气体。根据运动持续时间前75%、90%和100%的数据计算OUES。我们还测定了以下次最大量变量：通气无氧阈（VAT）、分钟通气量与二氧化碳产生量关系的回归线斜率（VE-VCO2斜率）以及推算最大摄氧量（EMOC）。我们分析了OUES和其他次最大量变量与VO2max的关系，并研究了次最大量运动对OUES的影响。

结果

对数曲线拟合模型的相关系数为0.978±0.016（均值±标准差）。OUES与VO2max具有显著相关性（r = 0.941，p < 0.0001）。VO2max与OUES之间的相关性强于VO2max与VAT、VE-VCO2斜率或EMOC之间的相关性。运动100%和90%时的OUES值彼此无差异（在α值为0.05且治疗效果为170时，检验效能[1-β]为0.90）；运动75%时的OUES略低（3.5%）。