Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan.
J Clin Psychiatry. 2021 May 11;82(3):20m13644. doi: 10.4088/JCP.20m13644.
Several case reports have suggested an association between obsessive-compulsive disorder (OCD) and dementia. However, the exact relationship remains unclear.
Using the Taiwan National Health Insurance Research Database, 1,347 patients with OCD (ICD-9-CM code 300.3) aged ≥ 45 years and 13,470 controls matched for age, sex, residence, income, and dementia-related comorbidities were included between 1996 and 2013 for investigation of subsequent dementia from enrollment to the end of 2013. Stratified Cox regression analysis on each matched pair was applied to assess the dementia risk between the OCD and control groups. The analysis for the current study was performed in 2018.
Patients with OCD had increased risk of developing any dementia (hazard ratio [HR] = 4.28; 95% confidence interval [CI], 2.96-6.21), Alzheimer's disease (HR = 4.04; 95% CI, 1.55-10.54), and vascular dementia (HR = 3.95; 95% CI, 1.70-9.18) compared with controls.
Future research on the pathogenic mechanisms and molecular underpinnings of the relationship between OCD and dementia may lead to the development of novel therapeutics.
几项病例报告表明强迫症（OCD）与痴呆之间存在关联。然而，确切的关系仍不清楚。
使用台湾全民健康保险研究数据库，纳入了 1996 年至 2013 年间年龄≥45 岁的 1347 例 OCD 患者（ICD-9-CM 代码 300.3）和 13470 例年龄、性别、居住地、收入和与痴呆相关的合并症相匹配的对照者，以调查从入组到 2013 年底的后续痴呆情况。对每一对匹配者应用分层 Cox 回归分析评估 OCD 组和对照组之间的痴呆风险。本研究的分析于 2018 年进行。
与对照组相比，OCD 患者发生任何类型痴呆（风险比 [HR] = 4.28；95%置信区间 [CI]，2.96-6.21）、阿尔茨海默病（HR = 4.04；95% CI，1.55-10.54）和血管性痴呆（HR = 3.95；95% CI，1.70-9.18）的风险增加。
未来关于 OCD 和痴呆之间关系的发病机制和分子基础的研究可能会导致新疗法的开发。
