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全血细胞减少作为前列腺癌的初始表现:一例病例报告

Pancytopenia as an initial manifestation of prostate cancer: a case report.

作者信息

da Silva Marcos Antonio Custódio Neto, Manhães Vitor Pimentel Rodrigues, Gasparotto Júnior Luadir, Tsukumo Daniela Miti Lemos, Lalli Cristina Alba

机构信息

Faculty of Medical Science, Medical Residency Program in Internal Medicine, Clinical Hospital from State University of Campinas, Rua Tessália Vieira de Camargo, 126. Cidade Universitária Zeferino Vaz. CEP, 13083-887, Campinas, Sao Paulo, Brasil.

出版信息

J Med Case Rep. 2021 May 19;15(1):247. doi: 10.1186/s13256-021-02843-0.

Abstract

BACKGROUND

Prostate adenocarcinoma is the most frequent cancer type among men, followed by skin cancer. Patients with prostate cancer usually present lower urinary tract symptoms due to tumor involvement. Bone marrow invasion is associated with prostate cancer metastasis and is common if blastic lesions in bones are present but is very rare without a large bone involvement and uncommon as initial presentation.

CASE PRESENTATION

We present a case of an 86-year-old Caucasian man with bone marrow invasion of prostate cancer without urological or bone-related symptoms and without prostate nodules. His findings were dyspnea, fatigue, and tachycardia. We detail the complete investigation of the case until we found the accurate diagnosis. The patient started treatment, but he had no response and so the oncology team started palliative care.

CONCLUSION

Bone marrow invasion as an initial manifestation of prostate cancer is not common, especially if no prostatic lesions are found. This report is important to provide additional information about prostate cancer management.

摘要

背景

前列腺腺癌是男性中最常见的癌症类型,其次是皮肤癌。前列腺癌患者通常因肿瘤侵犯而出现下尿路症状。骨髓侵犯与前列腺癌转移相关,若骨骼出现成骨性病变则较为常见,但在无大面积骨骼受累的情况下非常罕见,且很少作为初始表现出现。

病例介绍

我们报告一例86岁的白种男性患者,患有前列腺癌骨髓侵犯,但无泌尿系统或骨骼相关症状,也没有前列腺结节。他的症状为呼吸困难、疲劳和心动过速。我们详细介绍了该病例的全面检查过程,直至做出准确诊断。患者开始接受治疗,但无反应,因此肿瘤学团队开始进行姑息治疗。

结论

骨髓侵犯作为前列腺癌的初始表现并不常见,尤其是在未发现前列腺病变的情况下。本报告对于提供有关前列腺癌治疗的更多信息具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/8132390/e726ab38aad2/13256_2021_2843_Fig1_HTML.jpg

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