Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.
Sci Rep. 2021 May 18;11(1):10547. doi: 10.1038/s41598-021-90178-7.
Previous studies on the association between thyroid function and body composition are conflicting and showed strong differences across age groups. Our aim was to clarify age-specific associations of serum thyroid-stimulating hormone (TSH) levels with markers of body composition including body mass index (BMI), waist circumference, fat mass (FM), fat-free mass (FFM) and body cell mass (BCM). We used data from two independent population-based cohorts within the framework of the Study of Health in Pomerania. The study population included 5656 individuals aged 20 to 90 years. Markers of body composition were measured by bioelectrical impedance analysis. Serum TSH levels were significantly positively associated with BMI (β = 0.16; 95% confidence interval [CI]: 0.06 to 0.27), waist circumference (β = 0.35; 95% CI: 0.08 to 0.62) and FM (β = 0.32; 95% CI: 0.12 to 0.52), but not with FFM and BCM. Interaction analysis revealed positive associations of serum TSH levels with BMI, waist circumference, FM, FFM and BCM in individuals older than 60 years, while no such associations were observed in younger individuals. We demonstrated that lower serum TSH levels were accompanied with lower values of BMI, waist circumference, FM, FFM, and BCM in the elderly, while no such associations were observed in younger individuals.
先前关于甲状腺功能与身体成分之间关联的研究结果存在冲突，并且在不同年龄组之间存在很大差异。我们的目的是阐明血清促甲状腺激素（TSH）水平与身体成分标志物（包括体重指数 [BMI]、腰围、脂肪量 [FM]、去脂体重 [FFM] 和身体细胞量 [BCM]）之间的特定年龄相关性。我们使用了波美拉尼亚健康研究框架内的两个独立的基于人群的队列的数据。研究人群包括 5656 名年龄在 20 至 90 岁之间的个体。身体成分标志物通过生物电阻抗分析进行测量。血清 TSH 水平与 BMI（β=0.16；95%置信区间 [CI]：0.06 至 0.27）、腰围（β=0.35；95%CI：0.08 至 0.62）和 FM（β=0.32；95%CI：0.12 至 0.52）呈显著正相关，但与 FFM 和 BCM 无关。交互分析显示，血清 TSH 水平与 BMI、腰围、FM、FFM 和 BCM 在年龄大于 60 岁的个体中呈正相关，而在年轻个体中则无此相关性。我们证明，在老年人中，较低的血清 TSH 水平伴随着较低的 BMI、腰围、FM、FFM 和 BCM 值，而在年轻个体中则无此相关性。
