Turbow Sara, Shah Kruti, Penziner Katherine, Knauss Michael
Division of General Medicine and Geriatrics, Department of Medicine, Emory University School of Medicine, Atlanta, GA.
Department of Pharmacy Services, Grady Health System, Atlanta, GA.
Innov Pharm. 2019 Aug 31;10(2). doi: 10.24926/iip.v10i2.1999. eCollection 2019.
The goal of this study was to determine if a pharmacist-led intervention to improve medication safety at hospital discharge reduced the number of hospital readmissions among geriatric high-utilizer patients. This study is the first to test a pharmacist-based intervention in a high-utilizer population.
This was a quasi-experimental pilot study done at a safety-net hospital in the southeastern US. Fifty-seven patients 65 years old and older who were in the 95th percentile for number of hospital admissions in a year were included. On the day of discharge, one of the study pharmacists reviewed the discharge medication list and calculated the Medication Appropriateness Index (MAI) for each medication and reviewed for Beers Criteria. Any medication identified as potentially high-risk or inappropriate was flagged by the pharmacist and discussed with the team. The primary outcome was the number of admissions in the year following the intervention in the intervention group versus the control group.
There were no statistically significant differences in the number of admissions, the MAI scores, or the number of medications meeting Beers Criteria between the two groups.
Although this study did not demonstrate a decrease in hospital admissions, it shows that pharmacist review of medications at discharge can identify potentially unnecessary medications that could lead to confusion or adverse events. Further research is necessary to identify interventions to prevent readmissions in this high-risk population.
本研究的目的是确定由药剂师主导的、旨在提高出院时用药安全性的干预措施是否能减少老年高使用量患者的再次入院次数。本研究是首次在高使用量人群中测试基于药剂师的干预措施。
这是一项在美国东南部一家安全网医院进行的准实验性试点研究。纳入了57名65岁及以上且年住院次数处于第95百分位数的患者。在出院当天,一名研究药剂师审查出院用药清单,计算每种药物的用药适宜性指数(MAI)并对照《Beers标准》进行审查。药剂师标记出任何被确定为潜在高风险或不适当的药物,并与团队进行讨论。主要结局是干预组与对照组在干预后一年的入院次数。
两组在入院次数、MAI评分或符合《Beers标准》的药物数量方面均无统计学上的显著差异。
尽管本研究未显示入院次数减少,但表明药剂师在出院时对药物进行审查可以识别出可能导致困惑或不良事件的潜在不必要药物。有必要进行进一步研究以确定在这一高风险人群中预防再次入院的干预措施。