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利用生物化学知识向学生传授社会表观遗传学与健康差距之间的因果联系。

Using Biochemistry to Educate Students on the Causal Link between Social Epigenetics and Health Disparities.

作者信息

Diaz-Cruz Edgar S, Harland Michael D, Darensbourg Caleb

机构信息

Belmont University College of Pharmacy.

出版信息

Innov Pharm. 2020 Jul 31;11(3). doi: 10.24926/iip.v11i3.2418. eCollection 2020.

Abstract

BACKGROUND

While pharmacy education standards require students to recognize social determinants of health (SDOH), there is an opportunity to improve how this is taught in the curriculum. One innovative approach is to educate student pharmacists in a biochemistry course through the integration of topics like epigenetics using SDOH as the framework.

INNOVATION

A 50-minute educational activity was used to supplement material on the regulation of gene expression, in which epigenetic changes are driven by SDOH. It provided students with a biochemical basis to explain some health disparities, rather than viewing them exclusively as social obstacles to health. The activity employed a mini-lecture, a short video, as well as both small and large group discussion. A reflective paper was used to assess students' understanding of the topic, and the role of the pharmacist in helping patients prevent diseases caused by epigenetic changes due to social determinants of health.

FINDINGS

A post-activity survey showed that the activity increased students' perception of knowledge about SDOH, as well as the effect of epigenetic changes on health outcomes. Furthermore, this activity increased students' awareness about the role that SDOH play in epigenetic changes and challenged students to understand the role that society plays in health outcomes.

CONCLUSIONS

The preventable nature of health inequities creates an opportunity to integrate public health into pharmacy education. The integration of epigenetics and SDOH gives the student an opportunity to provide a mechanistic link between social inequities and biochemical processes.

摘要

背景

虽然药学教育标准要求学生认识到健康的社会决定因素(SDOH),但在课程中教授这方面内容仍有改进空间。一种创新方法是在生物化学课程中,以SDOH为框架,通过整合表观遗传学等主题来培养学生药剂师。

创新

开展了一项50分钟的教育活动,以补充关于基因表达调控的内容,其中表观遗传变化由SDOH驱动。该活动为学生提供了一个生化基础,用以解释一些健康差异,而不是仅仅将其视为健康的社会障碍。活动采用了小型讲座、短视频以及小组和大组讨论。通过一篇反思性论文来评估学生对该主题的理解,以及药剂师在帮助患者预防由健康的社会决定因素导致的表观遗传变化所引发疾病方面的作用。

研究结果

活动后的调查显示,该活动提高了学生对SDOH知识的认知,以及表观遗传变化对健康结果的影响。此外,这项活动增强了学生对SDOH在表观遗传变化中所起作用的认识,并促使学生理解社会在健康结果中所起的作用。

结论

健康不平等的可预防性为将公共卫生融入药学教育创造了机会。表观遗传学与SDOH的整合使学生有机会在社会不平等与生化过程之间建立起一种机制联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7161/8075150/869e57c16b84/21550417-11-03-2418-g1.jpg

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