Snyder J R, Olander H J, Pascoe J R, Holland M, Kurpershoek C J
Veterinary Medical Teaching Hospital, Department of Surgery, Davis, CA.
Am J Vet Res. 1988 Jun;49(6):801-9.
Morphologic changes that develop sequentially in the large colon during experimentally induced ischemia were documented in 14 halothane-anesthetized horses. Colonic ischemia was induced by 4 types of vascular occlusion, 24 cm proximal and distal to the pelvic flexure. The effect of transmural (colonic wall) vascular compression combined with either venous occlusion (3 horses, group A) or venous and arterial occlusion (3 horses, group B) of the colonic vessels was studied for 1, 2, and 6 hours of occlusion. Also observed was the effect of reperfusion for 0.5 hour after release of the clamps for the 1- and 2-hour occlusions and for 1 hour after release of the clamps for the 6-hour occlusion. Effects of occluding only the colonic veins (4 horses, group C), or the colonic veins and arteries (4 horses, group D) were studied for 0.5, 1, 1.5, and 2 hours of occlusion and during reperfusion for 0.5 hour. Full-thickness intestinal biopsy specimens were obtained from the antimesenteric border of the pelvic flexure at 0, 0.25, 0.5, 0.75, 1, 1.5, and 2 hours during occlusion and at 0.5 hour after release of vascular occlusion. Biopsy specimens were obtained at hourly intervals from the 2 horses in which 6-hour occlusion was performed and at 1 hour after release of vascular occlusion. Macroscopic changes (serosal color, mucosal color, serum leakage) in the colon were recorded.(ABSTRACT TRUNCATED AT 250 WORDS)
在14匹接受氟烷麻醉的马身上记录了实验性诱导缺血期间在大结肠中依次发生的形态学变化。结肠缺血通过4种类型的血管闭塞诱导，在骨盆弯曲处近端和远端24厘米处进行。研究了结肠壁血管压迫联合结肠血管静脉闭塞（3匹马，A组）或静脉和动脉闭塞（3匹马，B组）1、2和6小时的效果。还观察了在1小时和2小时闭塞的夹子松开后0.5小时再灌注的效果，以及6小时闭塞的夹子松开后1小时再灌注的效果。研究了仅闭塞结肠静脉（4匹马，C组）或结肠静脉和动脉（4匹马，D组）0.5、1、1.5和2小时闭塞以及再灌注0.5小时的效果。在闭塞期间的0、0.25、0.5、0.75、1、1.5和2小时以及血管闭塞松开后0.5小时，从骨盆弯曲的系膜对侧缘获取全层肠活检标本。对进行6小时闭塞的2匹马，每隔1小时获取活检标本，并在血管闭塞松开后1小时获取。记录结肠的宏观变化（浆膜颜色、粘膜颜色、血清渗漏）。（摘要截断于250字）
