LASUCOM.
Niger J Physiol Sci. 2020 Dec 31;35(2):123-129.
Salt-sensitivity is more common in blacks than whites but the underlying cause is not fully known. Atrial natriuretic peptide (ANP) concentrations might play a role. This study investigated plasma ANP concentrations and effect of salt-loading in salt-sensitive (SS) and salt-resistant (SR) normotensive (NT) and hypertensive (HT) Nigerians of both genders Forty-three (43) apparently healthy (NT) adult volunteers and thirty-seven (37) age-matched newly diagnosed (HT) Nigerians were grouped into SS and SR volunteers based on the mean changes in their mean arterial blood pressure ≥ 5 mmHg, following a 5-day administration of 200 mmol of sodium in each of the volunteers. ANP concentrations were determined before and after salt loading. Prevalence of SS and SR in the NT and HT Nigerians was 51.2% and 48.8%, respectively. Basal ANP levels in SS and SR NT and HT participants were similar but salt significantly raised ANP concentrations in SS (p < 0.01), SR (p < 0.001) NT volunteers only. Besides, basal ANP concentrations observed in SS and SR NT and HT males and females were similar but salt loading significantly increased ANP levels in SS NT males (p <0.05), SR NT (p < 0.001) and HT (p < 0.05) females only. These findings showed that salt-sensitive hypertensive individuals demonstrated a blunted ANP response to salt loading. However, salt-resistant normotensive volunteers showed a significant increase in ANP concentrations. with higher levels in NT females than males. The impaired ANP response to salt challenge might be the basis for the higher prevalence of salt-sensitivity among blacks.
盐敏感性在黑种人中比在白种人中更为常见，但潜在原因尚不完全清楚。心钠肽（ANP）浓度可能起作用。本研究调查了盐敏感（SS）和盐抵抗（SR）的正常血压（NT）和高血压（HT）尼日利亚人群的血浆 ANP 浓度和盐负荷的影响 43 名（43 名）明显健康的（NT）成年志愿者和 37 名年龄匹配的新诊断的（HT）尼日利亚人根据他们的平均动脉血压的平均变化分组为 SS 和 SR 志愿者，在每位志愿者中连续 5 天给予 200mmol 的钠后，平均动脉血压变化≥5mmHg。在盐负荷前后测定 ANP 浓度。NT 和 HT 尼日利亚人中 SS 和 SR 的患病率分别为 51.2%和 48.8%。SS 和 SR NT 和 HT 参与者的基础 ANP 水平相似，但盐显著升高 SS（p<0.01），SR（p<0.001）NT 志愿者仅升高。此外，在 SS 和 SR NT 和 HT 男性和女性中观察到的基础 ANP 浓度相似，但盐负荷仅显著增加 SS NT 男性（p<0.05），SR NT（p<0.001）和 HT（p<0.05）女性的 ANP 水平。这些发现表明，盐敏感的高血压个体对盐负荷的 ANP 反应减弱。然而，盐抵抗的正常血压志愿者显示出 ANP 浓度的显著增加。NT 女性的水平高于男性。对盐挑战的 ANP 反应受损可能是黑种人中盐敏感性患病率较高的基础。
