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Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria..
Niger J Physiol Sci. 2020 Dec 31;35(2):181-186.
The straw-coloured fruit bats (Eidolon helvum) are the most widely distributed megachiropteran species in Africa. Studies have shown that they migrate, and are likely exposed to environmental pollutants across population. This study was designed to investigate genotoxicity via the bone marrow micronucleus assay and haematological alterations of Eidolon helvum in the tropics. Healthy straw-coloured fruit bats (Eidolon helvum; n=20) were captured from two geographical regions, Ogun and Gombe States in Nigeria and were grouped based on sex and age. Blood samples were collected for haematology and osmotic fragility, and bone marrow samples for genotoxicity studies. Results showed no significant differences in erythrocytes and leucocytes values across age and sex. The erythrocytes osmotic fragility was higher in juvenile than in adults at 0 and 0.1%NaCl, while it was higher in adult males than in adult females at 0 and 0.3% NaCl. The erythrocytes and leucocytes parameters in straw colored fruit bats were within the reference values seen in literature except the higher monocyte counts suggesting chronic inflammation. There were increased levels of micronucleated polychromatic erythrocytes and normochromatic erythrocytes in the straw-coloured fruit bats indicating genotoxicity and cytotoxicity, respectively. The present study provided baseline research data on the haematology and micronucleus profile of the straw-coloured fruit bats in Nigeria. This is perhaps the first study on haematology and micronucleus assay of in straw-colored fruit bats in the tropics.
稻草色果蝠（Eidolon helvum）是非洲分布最广泛的大型翼手目物种。研究表明，它们会迁徙，并可能在种群之间接触到环境污染物。本研究旨在通过骨髓微核试验和热带地区的 Eidolon helvum 血液学改变来研究遗传毒性。从尼日利亚的奥贡州和贡贝州两个地理区域捕获了 20 只健康的稻草色果蝠（Eidolon helvum），并根据性别和年龄进行分组。采集血液样本进行血液学和渗透脆性检测，以及骨髓样本进行遗传毒性研究。结果表明，年龄和性别之间红细胞和白细胞值没有显著差异。在 0 和 0.1%NaCl 时，幼年稻草色果蝠的红细胞渗透脆性高于成年，而在 0 和 0.3%NaCl 时，成年雄性的红细胞渗透脆性高于成年雌性。稻草色果蝠的红细胞和白细胞参数均在文献中所见的参考值范围内，除单核细胞计数较高提示慢性炎症外。稻草色果蝠的多色红细胞和正常红细胞中的微核红细胞数量增加，分别表明遗传毒性和细胞毒性。本研究为尼日利亚稻草色果蝠的血液学和微核图谱提供了基线研究数据。这也许是热带地区首次对稻草色果蝠的血液学和微核试验进行的研究。
