Department of Child Health and Diseases, Department of Pediatric Gastroenterology, Gülhane Training and Research Hospital, Ankara, Turkey.
Dig Dis. 2022;40(3):276-281. doi: 10.1159/000517263. Epub 2021 May 19.
Most studies of the relationship between duodenogastric reflux (DGR) and Helicobacter pylori have reported that the presence of DGR decreases H. pylori colonization, while H. pylori infection increases the frequency of DGR by impairing antroduodenal motility. The present study aimed to investigate the relationship between primary DGR and the prevalence of H. pylori in children, as well as the degree of colonization and the presence and severity of gastritis.
Included in the study were 410 patients between the ages of 2 and 18 years, referred to the pediatric gastroenterology clinic with complaints of dyspepsia, abdominal pain, and nausea/vomiting, who underwent upper gastrointestinal system endoscopic examination and stomach biopsy. The study group included 60 patients with DGR, while 350 non-DGR patients formed the control group.
The mean age of patients with DGR was 15.7 ± 2.1 years, while the mean age of the control group was 14.2 ± 3.8 years (p = 0.02). Of those with DGR, 50 (83.3%) were girls, while in the control group, 215 (61.4%) were girls (p = 0.001). Of patients with DGR, 16 were H. pylori (+) (26.7%), while in the control group, 168 were H. pylori (+) (48%) (p = 0.002). There was no significant difference between the 2 groups with respect to H. pylori degree of colonization (p = 0.08). Gastritis was present in 56 (93.3%) patients in the DGR group and 322 (92%) patients in the control group (p = 0.72). A significant difference was found between the 2 groups in terms of gastritis severity (p = 0.01).
The mean age of patients with DGR was significantly higher than that of patients without DGR, and DGR was found to be more common in girls. In patients with DGR, H. pylori prevalence was significantly lower than in those without DGR; however, no significant difference was found between the 2 groups with respect to the colonization degree.
大多数关于十二指肠胃反流（DGR）与幽门螺杆菌（H. pylori）关系的研究报告指出，DGR 的存在会降低 H. pylori 的定植，而 H. pylori 感染通过损害十二指肠运动，增加 DGR 的频率。本研究旨在探讨原发性 DGR 与儿童中 H. pylori 的流行率、定植程度以及胃炎的存在和严重程度之间的关系。
本研究纳入了 410 名年龄在 2 至 18 岁之间的患者，因消化不良、腹痛和恶心/呕吐症状就诊于儿科消化内科，接受了上消化道内镜检查和胃活检。研究组包括 60 例 DGR 患者，对照组为 350 例非 DGR 患者。
DGR 组患者的平均年龄为 15.7 ± 2.1 岁，对照组为 14.2 ± 3.8 岁（p = 0.02）。DGR 组中 50 例（83.3%）为女性，而对照组中 215 例（61.4%）为女性（p = 0.001）。DGR 组中 16 例（26.7%）为 H. pylori（+），而对照组中 168 例（48%）为 H. pylori（+）（p = 0.002）。两组 H. pylori 定植程度无显著差异（p = 0.08）。DGR 组 56 例（93.3%）患者和对照组 322 例（92%）患者存在胃炎（p = 0.72）。两组胃炎严重程度存在显著差异（p = 0.01）。
DGR 组患者的平均年龄显著高于非 DGR 组，且 DGR 多见于女性。DGR 组患者的 H. pylori 流行率显著低于非 DGR 组，但两组患者的定植程度无显著差异。
