主动脉钙化增加胃癌患者胃切除术后吻合口漏的风险。
Aorta Calcification Increases the Risk of Anastomotic Leakage After Gastrectomy in Gastric Cancer Patients.
作者信息
Tao Wei, Cheng Yu-Xi, Zou Ying-Ying, Peng Dong, Zhang Wei
机构信息
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.
出版信息
Cancer Manag Res. 2021 May 12;13:3857-3865. doi: 10.2147/CMAR.S306942. eCollection 2021.
PURPOSE
The purpose of the present study was to evaluate whether vascular calcification is a risk factor for anastomotic leakage after gastrectomy in gastric cancer patients.
METHODS
Patients with confirmed gastric cancer were collected from the database of a single clinical center from January 2013 to January 2019. The calcification score and anastomotic leakage were recorded, and predictors of anastomotic leakage were analyzed.
RESULTS
A total of 856 patients were included in this study; 818 patients had no anastomotic leakage, and 38 patients had anastomotic leakage. The ratio of hypertension status (p=0.011), open gastrectomy (p=0.012), postoperative length of stay (p=0.000), aorta calcification score (p=0.000) and celiac axis calcification (p=0.000) were higher in the anastomotic leakage group than in the nonanastomotic leakage group. In multivariate analysis, aorta calcification (p=0.029, odds ratio =2.425, 95% CI=1.095-5.491) was an independent predictor of the anastomotic leakage.
CONCLUSION
Aorta calcification is an independent risk factor for anastomotic leakage after gastrectomy in gastric cancer patients.
目的
本研究旨在评估血管钙化是否为胃癌患者胃切除术后吻合口漏的危险因素。
方法
收集2013年1月至2019年1月单个临床中心数据库中确诊为胃癌的患者。记录钙化评分和吻合口漏情况，并分析吻合口漏的预测因素。
结果
本研究共纳入856例患者；818例患者无吻合口漏，38例患者发生吻合口漏。吻合口漏组的高血压状态比例（p = 0.011）、开腹胃切除术比例（p = 0.012）、术后住院时间（p = 0.000）、主动脉钙化评分（p = 0.000）和腹腔动脉钙化比例（p = 0.000）均高于无吻合口漏组。多因素分析显示，主动脉钙化（p = 0.029，比值比=2.425，95%可信区间=1.095 - 5.491）是吻合口漏的独立预测因素。
结论
主动脉钙化是胃癌患者胃切除术后吻合口漏的独立危险因素。
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