Yu Xiao, Yang Xi, Zhao Yue, Luo Xiao-Ping, Liang Yan, Wu Wei, Ying Yan-Qin, Ye Feng, Hou Ling
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Transl Pediatr. 2021 Apr;10(4):783-789. doi: 10.21037/tp-20-366.
To compare the physical development status, level of blood glucose and lipid metabolism in small for gestational age (SGA) and appropriate for gestational age (AGA) groups with central precocious puberty (CPP).
This was a retrospective study. Three hundred and twenty-two girls with CPP were divided into the AGA group (304 cases) and the SGA group (18 cases). Physical index such as height, weight, and body mass index (BMI), as well as sex hormones, adrenal androgens, blood lipid levels, fasting blood glucose, insulin levels, and homeostasis model assessment of insulin resistance (HOMA-IR) were compared between the two groups.
Height, weight, and BMI in the SGA group were lower than those in the AGA group (P<0.05). The level of LH/FSH, estradiol, testosterone, DHEA and androstenedione had no significant difference between the SGA group and AGA group (P>0.05). The fasting blood glucose, insulin level, HOMA-IR, high-density lipoprotein (HDL) and the average level of triglycerides were similar between these two groups (P>0.05). There was a statistically significant difference in total cholesterol and low-density lipoprotein (LDL) between the two groups (P<0.05). However, the blood lipids and blood glucose in both groups were within the normal range.
The height, weight, BMI, serum cholesterol and LDL of girls in SGA with CPP were significantly lower than that of those girls born AGA.
比较小于胎龄儿（SGA）和适于胎龄儿（AGA）合并中枢性性早熟（CPP）的身体发育状况、血糖及脂质代谢水平。
本研究为回顾性研究。322例CPP女童被分为AGA组（304例）和SGA组（18例）。比较两组的身高、体重、体重指数（BMI）等身体指标，以及性激素、肾上腺雄激素、血脂水平、空腹血糖、胰岛素水平和胰岛素抵抗稳态模型评估（HOMA-IR）。
SGA组的身高、体重和BMI低于AGA组（P<0.05）。SGA组与AGA组的LH/FSH、雌二醇、睾酮、脱氢表雄酮和雄烯二酮水平无显著差异（P>0.05）。两组的空腹血糖、胰岛素水平、HOMA-IR、高密度脂蛋白（HDL）和甘油三酯平均水平相似（P>0.05）。两组的总胆固醇和低密度脂蛋白（LDL）有统计学显著差异（P<0.05）。然而，两组的血脂和血糖均在正常范围内。
SGA合并CPP女童的身高、体重、BMI、血清胆固醇和LDL显著低于AGA出生的女童。
