Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Adv Exp Med Biol. 2021;1311:189-204. doi: 10.1007/978-3-030-65768-0_14.
Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME), play an important role in cancer initiation, progression, and metastasis. Recent findings have demonstrated that the TME not only provides physical support for cancer cells but also directs cell-to-cell interactions (in this case, the interaction between cancer cells and CAFs). As cancer progresses, the CAFs also coevolve, transitioning from an inactivated state to an activated state. The elucidation and understanding of the interaction between cancer cells and CAFs will pave the way for new cancer therapies [1-3].
癌症相关成纤维细胞（CAFs）是肿瘤微环境（TME）的主要组成部分，在癌症的发生、发展和转移中发挥着重要作用。最近的研究结果表明，TME 不仅为癌细胞提供物理支持，还指导细胞间的相互作用（在这种情况下，是癌细胞与 CAFs 之间的相互作用）。随着癌症的进展，CAFs 也共同进化，从失活状态转变为激活状态。阐明和理解癌细胞与 CAFs 之间的相互作用将为新的癌症治疗方法铺平道路[1-3]。
