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Secondary structure prediction of liver microsomal cytochrome P-450; proposed model of spatial arrangement in a membrane.

作者信息

Hudecek J, Anzenbacher P

机构信息

Department of Biochemistry, Charles University, Prague, Czechoslovakia.

出版信息

Biochim Biophys Acta. 1988 Aug 10;955(3):361-70. doi: 10.1016/0167-4838(88)90216-6.

DOI:10.1016/0167-4838(88)90216-6
PMID:3401494
Abstract

The secondary structure of rabbit liver microsomal cytochrome P-450 LM2, rat liver microsomal cytochromes P-450b and P-450e (phenobarbital-inducible), and rat liver microsomal cytochromes P-450c, P-450d (3-methylcholanthrene-inducible) was predicted by a combination of methods (i) identifying the transmembrane parts of integral membrane proteins, and (ii) statistically predicting the secondary structure of globular proteins. The results are similar for all phenobarbital-inducible enzymes and make it possible to construct two structural models with seven or four transmembrane alpha-helices. The cytochromes of the second group obviously form a second structural family with four membrane-spanning alpha-helices. In both cases, a large ectodomain with several consecutive alpha-helices, which may provide the heme-binding pocket, is exposed out of the membrane.

摘要

相似文献

1
Secondary structure prediction of liver microsomal cytochrome P-450; proposed model of spatial arrangement in a membrane.
Biochim Biophys Acta. 1988 Aug 10;955(3):361-70. doi: 10.1016/0167-4838(88)90216-6.
2
Induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by a series of 4'-substituted-2,3,4,5-tetrachlorobiphenyls.一系列4'-取代-2,3,4,5-四氯联苯对大鼠肝脏微粒体细胞色素P-450同工酶和环氧化物水解酶的诱导作用。
Toxicology. 1988 Dec 30;53(2-3):289-300. doi: 10.1016/0300-483x(88)90221-1.
3
Co-induction of cytochrome P-450 isozymes in rat liver by 2,4,5,2',4',5'-hexachlorobiphenyl or 3-methoxy-4-aminoazobenzene.2,4,5,2',4',5'-六氯联苯或3-甲氧基-4-氨基偶氮苯对大鼠肝脏细胞色素P-450同工酶的共诱导作用。
Mol Pharmacol. 1987 Aug;32(1):206-11.
4
Differential expression and function of three closely related phenobarbital-inducible cytochrome P-450 isozymes in untreated rat liver.未处理大鼠肝脏中三种密切相关的苯巴比妥诱导型细胞色素P-450同工酶的差异表达及功能
Arch Biochem Biophys. 1987 Aug 1;256(2):407-20. doi: 10.1016/0003-9861(87)90597-2.
5
Immunological identification and effects of 3-methylcholanthrene and phenobarbital on rat pulmonary cytochrome P-450.3-甲基胆蒽和苯巴比妥对大鼠肺细胞色素P-450的免疫学鉴定及影响
Cancer Res. 1987 Apr 1;47(7):1878-82.
6
Identification of the forms of cytochrome P-450 induced in rat liver by 2-acetylaminofluorene using immunoblotting and partial purification.使用免疫印迹法和部分纯化技术鉴定2-乙酰氨基芴诱导大鼠肝脏中细胞色素P-450的形式。
Biochem Biophys Res Commun. 1985 Apr 30;128(2):578-85. doi: 10.1016/0006-291x(85)90085-3.
7
Differential time course of induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by Aroclor 1254.Aroclor 1254对大鼠肝脏微粒体细胞色素P-450同工酶和环氧化物水解酶诱导的差异时程。
Arch Biochem Biophys. 1983 Aug;225(1):203-15. doi: 10.1016/0003-9861(83)90024-3.
8
[Identification of molecular forms of cytochrome P-450 isolated from liver microsomes of rats induced with phenobarbital and 3-methylcholanthrene].[从苯巴比妥和3-甲基胆蒽诱导的大鼠肝脏微粒体中分离出的细胞色素P-450分子形式的鉴定]
Biokhimiia. 1989 Mar;54(3):487-94.
9
[The level and activity of molecular forms of monooxygenase P-450b and P-450c during their separate and consecutive induction in the liver].
Biokhimiia. 1987 Apr;52(4):607-14.
10
Microheterogeneity in the major phenobarbital-inducible forms of rabbit liver microsomal cytochrome P-450 as revealed by nucleotide sequencing of cloned cDNAs.通过克隆cDNA的核苷酸测序揭示的兔肝微粒体细胞色素P-450主要苯巴比妥诱导形式中的微观异质性。
Biochemistry. 1988 Jan 12;27(1):73-80. doi: 10.1021/bi00401a013.

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2
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3
Interaction of 7-n-alkoxycoumarins with cytochrome P-450(2) and their partitioning into liposomal membranes. Assessment of methods for determination of membrane partition coefficients.
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Biochem J. 1992 Jun 1;284 ( Pt 2)(Pt 2):483-90. doi: 10.1042/bj2840483.