Alsomali Dunya Yunus, Bakshi Nasir, Kharfan-Dabaja Mohamed, El Fakih Riad, Aljurf Mahmoud
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Division of Hematology-Oncology, Mayo Clinic, Jacksonville, FL, USA.
Hematol Oncol Stem Cell Ther. 2023 Jan 17;16(2):110-116. doi: 10.1016/j.hemonc.2021.04.001.
The aim of this systematic review is to investigate different diagnostic methods and the available treatment options for subcutaneous panniculitis-like T-cell lymphoma (SPTCL).
We searched PubMed, Web of Science, SCOPUS, EBSCO, and CINAHL Plus for published case reports of SPTCL. From each record, we extracted data of the diagnostic methods, immunohistochemical profile, clinical characteristics, and the treatment approaches provided. Data were summarized and narratively synthesized to highlight the various diagnostic methods and treatment options of SPTCL.
Our literature search yielded 1293 unique citations. Following screening, nine articles reporting a total of 15 cases were included in this systematic review. All patients presented with subcutaneous nodules. Three of the 15 cases were initially misdiagnosed. The atypical lymphoid cells were positive for CD2, CD3, granzyme B, and TIA-1 and negative for CD1a, EBER, and CD20 in all the reported cases. The atypical lymphoid cells were positive for CD45RO in four out of seven cases, positive for CD56 in three out of 12 cases tested, while positive for CD5 and CD8 in the majority of cases. Therapy ranged from topical agents to immunosuppressive agents all the way to multiagent chemotherapy.
SPTCL is a rare lymphoma. Diagnosis is highly dependent on the immunohistochemical stains added to histopathologic and radiologic findings. Therapy is dependent on the pace of the disease, with encouraging results obtained with single-agent cyclosporine.
本系统评价旨在研究皮下脂膜炎样T细胞淋巴瘤（SPTCL）的不同诊断方法和可用治疗方案。
我们在PubMed、科学网、Scopus、EBSCO和CINAHL Plus中检索已发表的SPTCL病例报告。从每份记录中，我们提取了诊断方法、免疫组化特征、临床特征和所提供的治疗方法的数据。对数据进行总结并进行叙述性综合分析，以突出SPTCL的各种诊断方法和治疗方案。
我们的文献检索共获得1293条独特的引文。经过筛选，9篇报告共15例病例的文章被纳入本系统评价。所有患者均表现为皮下结节。15例中有3例最初被误诊。在所有报告的病例中，非典型淋巴细胞CD2、CD3、颗粒酶B和TIA-1呈阳性，而CD1a、EBER和CD20呈阴性。7例中有4例非典型淋巴细胞CD45RO呈阳性，12例中有3例检测的CD56呈阳性，而大多数病例中CD5和CD8呈阳性。治疗方法从局部用药到免疫抑制剂，再到多药化疗。
SPTCL是一种罕见的淋巴瘤。诊断高度依赖于组织病理学和放射学检查结果加上免疫组化染色。治疗取决于疾病的进展情况，单药环孢素取得了令人鼓舞的结果。
