Jung Hyun Min, Paik Jin Hui, Kim Sin Young, Hong Dae Young
Department of Emergency Medicine, Inha University School of Medicine, Incheon, South Korea.
Department of Emergency Medicine, Konkuk University School of Medicine, Seoul, South Korea.
Front Neurol. 2021 May 4;12:661689. doi: 10.3389/fneur.2021.661689. eCollection 2021.
Hyperglycemia and hypokalemia are common problems in patients with aneurysmal subarachnoid hemorrhage (aSAH). The aim of this study was to determine whether the plasma glucose to potassium ratio (GPR) predicts mortality due to aSAH. We prospectively recruited aSAH patients and healthy controls between March 2007 and May 2017. Clinical outcomes included mortality and poor outcome (modified Rankin scale score of 3-6) after 3 months. Multivariable analysis was used to determine the association between plasma GPR and 3-month mortality in aSAH patients. A total of 553 patients were recruited, and the mortality rate was 11%. The GPR was significantly elevated in aSAH patients compared with controls, in patients with a poor outcome than with a good outcome and in non-survivals than in survivals. Multivariable analysis showed that the plasma GPR was an independent factor associated with 3-month mortality. The area under the curve of the GPR was 0.747 in predicting 3-month mortality. The plasma GPR on admission has potential as a predictor of 3-month mortality in patients with aSAH.
高血糖和低钾血症是动脉瘤性蛛网膜下腔出血（aSAH）患者常见的问题。本研究的目的是确定血浆葡萄糖与钾比值（GPR）是否可预测aSAH导致的死亡率。我们在2007年3月至2017年5月期间前瞻性招募了aSAH患者和健康对照。临床结局包括3个月后的死亡率和不良结局（改良Rankin量表评分为3 - 6分）。采用多变量分析来确定aSAH患者血浆GPR与3个月死亡率之间的关联。共招募了553例患者，死亡率为11%。与对照组相比，aSAH患者的GPR显著升高，不良结局患者比良好结局患者的GPR显著升高，非存活者比存活者的GPR显著升高。多变量分析表明，血浆GPR是与3个月死亡率相关的独立因素。GPR预测3个月死亡率的曲线下面积为0.747。入院时的血浆GPR有可能作为aSAH患者3个月死亡率的预测指标。
