微小RNA在接受减肥手术的肥胖患者预后中的价值。
The value of miRNAs in the prognosis of obese patients receiving bariatric surgery.
作者信息
Liu Jiachen, Yang Danyue, Wang Biao, Zeng Yang, Li Weizheng
机构信息
Department of General Surgery, Third Xiangya Hospital, Central South University No. 138 Tongzipo Road Yuelu District, Changsha 410013, Hunan, People's Republic of China.
出版信息
Am J Transl Res. 2021 Apr 15;13(4):1905-1914. eCollection 2021.
Bariatric surgery has been the first-line treatment for obesity. Since the 2010s, gradual changes in miRNAs upon surgery have been observed. Substantial research has been undertaken on the role of bariatric surgery in the gastrointestinal tract. However, bariatric surgery research largely ignores the role of miRNAs in organs other than the gastrointestinal tract, while the contribution of miRNAs to this process has received little attention. This review addresses a neglected aspect of miRNAs in obese patients undergoing bariatric surgery, especially the obvious effect on multisystem organs. This finding provides evidence that miRNAs play a complex yet important role in the functional stability of each organ and the weight loss efficacy after bariatric surgery. The results provide a solid evidence base for the mechanism of bariatric surgery. Taking into account incompatible medication adherence associated with adverse outcomes, suggestions were identified for an efficient technical refinement of bariatric surgery with better clinical results.
减重手术一直是肥胖症的一线治疗方法。自21世纪10年代以来，人们观察到手术后miRNA会逐渐发生变化。关于减重手术在胃肠道中的作用，已经开展了大量研究。然而，减重手术研究在很大程度上忽略了miRNA在胃肠道以外器官中的作用，而miRNA对这一过程的贡献也很少受到关注。本综述探讨了接受减重手术的肥胖患者中miRNA被忽视的一个方面，特别是其对多系统器官的显著影响。这一发现为miRNA在减重手术后各器官功能稳定性和体重减轻效果中发挥复杂而重要的作用提供了证据。这些结果为减重手术的机制提供了坚实的证据基础。考虑到与不良结局相关的用药依从性不佳，我们提出了一些建议，以实现减重手术的有效技术改进，从而获得更好的临床效果。
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