Qu Yunping, Tang Wenyan, Hao Ming, Chen Xiao
Neonatalintensive Care Unit, Women's and Children's Hospital Pingxiang, Jiangxi Province, China.
Department of Neonatology, Jiangxi Maternal and Child Health Hospital Nanchang, Jiangxi Province, China.
Am J Transl Res. 2021 Apr 15;13(4):2626-2634. eCollection 2021.
To analyze the efficacy of hydroxyethyl starch (HES) combined with Ulinastatin (Uti) in the treatment of newborns with capillary leak syndrome (CLS).
A total of 60 newborns with CLS admitted to four hospitals were selected as the study subjects, and were randomly divided into the control group (n = 30) and the observation group (n = 30) in accordance with the random number table. The control group was treated with HES alone, while the observation group was treated with Uti combined with HES.
At 5 d after treatment, the incidence rates of systemic edema and pulmonary edema, the levels of CRP, NE, and BUN, and the duration for the improvement of systemic edema, pulmonary edema and NICU hospital stay in the control group were superior to those in the observation group, while the 24-h urine output, PaO and MAP levels, the levels of A, SCr, ALT, and IL-10 in the observation group were superior to those in the control group ( < 0.05). After 3 months of follow-up after treatment, the mortality rate of newborns in the observation group (13.33%) was lower than that in the control group (36.67%) ( < 0.05).
HES combined with Uti can effectively alleviate edema, control inflammatory levels, and improve hepatic and renal functions and neonatal survival rate of newborns with CLS.
分析羟乙基淀粉（HES）联合乌司他丁（Uti）治疗新生儿毛细血管渗漏综合征（CLS）的疗效。
选取4所医院收治的60例CLS新生儿作为研究对象，按照随机数字表法随机分为对照组（n = 30）和观察组（n = 30）。对照组单纯采用HES治疗，观察组采用Uti联合HES治疗。
治疗后5 d，对照组全身水肿、肺水肿发生率，CRP、NE、BUN水平，全身水肿、肺水肿改善时间及NICU住院时间均优于观察组，而观察组24 h尿量、PaO及MAP水平，A、SCr、ALT、IL - 10水平均优于对照组（P < 0.05）。治疗后随访3个月，观察组新生儿死亡率（13.33%）低于对照组（36.67%）（P < 0.05）。
HES联合Uti可有效减轻水肿，控制炎症水平，改善CLS新生儿肝肾功能及提高新生儿存活率。
