Liu Changming, He Yan, Xiao Gang, Ouyang Hui, Zhang Chan
The Third Department of Infection, The First Hospital of Changsha Changsha, Hu'nan Province, China.
Department of Infection, The Second Xiangya Hospital of Central South University Changsha, Hu'nan Province, China.
Am J Transl Res. 2021 Apr 15;13(4):3794-3799. eCollection 2021.
To explore the clinical application effect of noninvasive mechanical ventilation for patients with acquired immune deficiency syndrome (AIDS) complicated with pneumonia.
A prospective study was conducted on 86 patients with AIDS complicated with pneumocystis pneumonia. The patients were randomly divided into a control group and an experimental group, both of which were treated with conventional drugs. The control group was supplemented with oxygen via a mask, and the experimental group was additionally treated with noninvasive ventilator ventilation. The changes of arterial oxygen partial pressure, oxygenation index, respiratory frequency, pulse rate, serum albumin and other indicators between the two groups before and after treatment were observed. The patient's hospitalization time, overall improvement and mortality rate were compared.
Compared with those before treatment, the arterial oxygen partial pressure, oxygenation index, respiratory frequency, and pulse rate of the two groups of patients were significantly improved after treatment (P<0.05). The improvement of the experimental group after treatment was more significant than that of the control group, and the difference was statistically significant (P<0.001). After treatment, the proportion of recovery rate of serum albumin in the experimental group was 81.40%, which was significantly higher than that in the control group (53.49%), and the difference was statistically significant (P<0.05). Compared with the control group, hospitalization time, treatment improvement and mortality rate in the experimental group had significant advantages and statistical significance (P<0.05).
For AIDS patients complicated with pneumonia, noninvasive mechanical ventilation had obvious treatment effects, which could significantly improve respiratory function, reduce mortality rate, and increase recovery rate. It can be considered as a therapeutic method to be included in routine treatment protocols.
探讨无创机械通气在获得性免疫缺陷综合征（AIDS）合并肺炎患者中的临床应用效果。
对86例AIDS合并肺孢子菌肺炎患者进行前瞻性研究。将患者随机分为对照组和实验组，两组均采用常规药物治疗。对照组通过面罩吸氧，实验组加用无创呼吸机通气。观察两组治疗前后动脉血氧分压、氧合指数、呼吸频率、脉搏率、血清白蛋白等指标的变化。比较患者的住院时间、总体改善情况及死亡率。
与治疗前相比，两组患者治疗后的动脉血氧分压、氧合指数、呼吸频率及脉搏率均显著改善（P<0.05）。实验组治疗后的改善情况比对照组更显著，差异有统计学意义（P<0.001）。治疗后，实验组血清白蛋白恢复率为81.40%，显著高于对照组（53.49%），差异有统计学意义（P<0.05）。与对照组相比，实验组的住院时间、治疗改善情况及死亡率具有显著优势且有统计学意义（P<0.05）。
对于AIDS合并肺炎患者，无创机械通气有明显治疗效果，可显著改善呼吸功能，降低死亡率，提高恢复率。可考虑将其作为一种治疗方法纳入常规治疗方案。
