癫痫（El）小鼠和正常小鼠海马及杏仁核离散区域的锌含量。

Zinc content in discrete hippocampal and amygdaloid areas of the epilepsy (El) mouse and normal mice.

作者信息

Fukahori M, Itoh M, Oomagari K, Kawasaki H

机构信息

Department of Neuropsychiatry, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

出版信息

Brain Res. 1988 Jul 12;455(2):381-4. doi: 10.1016/0006-8993(88)90099-6.

DOI:10.1016/0006-8993(88)90099-6

PMID:3401788

Abstract

In the present study, zinc content was determined in discrete hippocampal and amygdaloid areas of 3 strains of mice (El, ddY and CBA) using an atomic absorption spectrophotometer. Zinc content was significantly lower in the dentate area of El strain compared to ddY and CBA strains. The El mouse is considered an animal model for epilepsy and the seizures in this mouse appear to originate in the hippocampus. The results suggest the possible involvement of hippocampal zinc in the pathophysiology of convulsive seizures in the epileptic mouse.

摘要

在本研究中，使用原子吸收分光光度计测定了3种品系小鼠（El、ddY和CBA）离散海马区和杏仁核区的锌含量。与ddY和CBA品系相比，El品系小鼠齿状区的锌含量显著较低。El小鼠被认为是癫痫的动物模型，该小鼠的癫痫发作似乎起源于海马体。结果表明，海马体锌可能参与了癫痫小鼠惊厥发作的病理生理学过程。