Santa Maria Diane, Lightfoot Marguerita, Nyamathi Adey, Businelle Michael, Paul Mary, Quadri Yasmeen, Padhye Nikhil, Jones Jennifer, Calvo Armijo Margarita
Cizik School of Nursing, University of Texas Health Science Center at Houston, Houston, TX, United States.
Center for AIDS Prevention Studies and UCSF Prevention Research Center, University of California San Francisco, San Francisco, CA, United States.
JMIR Res Protoc. 2021 May 21;10(5):e26716. doi: 10.2196/26716.
Youth experiencing homelessness are more likely than housed youth to experience premature death, suicide, drug overdose, pregnancy, substance use, and mental illness. Yet while youth experiencing homelessness are 6 to 12 times more likely to become infected with HIV than housed youth, with HIV prevalence as high as 16%, many do not access the prevention services they need. Despite adversities, youth experiencing homelessness are interested in health promotion programs, can be recruited and retained in interventions and research studies, and demonstrate improved outcomes when programs are tailored and relevant to them.
The study aims to compare the efficacy of a nurse case management HIV prevention and care intervention, titled Come As You Are, with that of usual care among youth experiencing homelessness aged 16 to 25 years.
The study is designed as a 2-armed randomized wait-list controlled trial. Participants (n=450) will be recruited and followed up for 9 months after the intervention for a total study period of 12 months. Come As You Are combines nurse case management with a smartphone-based daily ecological momentary assessment to develop participant-driven HIV prevention behavioral goals that can be monitored in real-time. Youth in the city of Houston, Texas will be recruited from drop-in centers, shelters, street outreach programs, youth-serving organizations, and clinics.
Institutional review board approval (Committee for the Protection of Human Subjects, University of Texas Health Science Center at Houston) was obtained in November 2018. The first participant was enrolled in November 2019. Data collection is ongoing. To date, 123 participants have consented to participate in the study, 89 have been enrolled, and 15 have completed their final follow-up.
There is a paucity of HIV prevention research regarding youth experiencing homelessness. Novel and scalable interventions that address the full continuum of behavioral and biomedical HIV prevention are needed. This study will determine whether a personalized and mobile HIV prevention approach can reduce HIV risk among a hard-to-reach, transient population of youth at high risk.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/26716.
与有住所的青少年相比，无家可归的青少年更有可能过早死亡、自杀、药物过量、怀孕、使用毒品和患有精神疾病。然而，尽管无家可归的青少年感染艾滋病毒的可能性比有住所的青少年高6至12倍，艾滋病毒感染率高达16%，但许多人无法获得他们所需的预防服务。尽管面临逆境，无家可归的青少年对健康促进项目感兴趣，可以被招募并留在干预措施和研究中，并且当项目是为他们量身定制且与他们相关时，他们会表现出更好的结果。
本研究旨在比较名为“本色而来”的护士个案管理艾滋病毒预防和护理干预措施与常规护理措施对16至25岁无家可归青少年的疗效。
本研究设计为双臂随机等待名单对照试验。将招募参与者（n = 450），并在干预后随访9个月，总研究期为12个月。“本色而来”将护士个案管理与基于智能手机的每日生态瞬时评估相结合，以制定由参与者驱动的艾滋病毒预防行为目标，并可实时监测。将从德克萨斯州休斯顿市的临时接待中心、收容所、街头外展项目、青少年服务组织和诊所招募青少年。
2018年11月获得了机构审查委员会的批准（休斯顿德克萨斯大学健康科学中心人类受试者保护委员会）。第一名参与者于2019年11月入组。数据收集正在进行中。迄今为止，已有123名参与者同意参加该研究，89名已入组，15名已完成最终随访。
关于无家可归青少年的艾滋病毒预防研究匮乏。需要新颖且可扩展的干预措施，以解决行为和生物医学艾滋病毒预防的整个连续过程。本研究将确定个性化的移动艾滋病毒预防方法是否可以降低难以接触到的、流动的高风险青少年群体中的艾滋病毒风险。
国际注册报告识别码（IRRID）：DERR1-10.2196/26716。
