Department of Nephrology, Monash Health, Monash Medical Centre, Melbourne, Vic., Australia.
Department of Medicine, Monash University, Melbourne, Vic., Australia.
Int J Rheum Dis. 2021 Jul;24(7):904-911. doi: 10.1111/1756-185X.14131. Epub 2021 May 21.
Although antineutrophil cytoplasmic antibody-associated vasculitis (AAV) most commonly affects older individuals, many patients develop the disease during their most productive working years. The aim of this study was to examine the effects of AAV on employment and work disability in a cohort of Australian patients of working age.
Patients attending a vasculitis clinic located in Melbourne, Australia, completed an employment questionnaire in addition to the Work Productivity and Activity Impairment Questionnaire: Specific Health Problem.
The average age of the 47 respondents was 47.8 ± 11.9 years (range 22-63 years), with a median disease duration of 60 months (range 10.2-318.5 months). There were 68.1% who were currently employed, but 20.6% of respondents employed at the time of diagnosis were no longer working and 10.6% had experienced a significant reduction in work hours since their diagnosis. There were 12.7% who were dependent on the disability support pension. The rate of work disability was 23.4%. Many participants considered themselves work impaired (41.9%), with 10.1% having missed work in the previous week. Furthermore, 44.7% of respondents reported that their financial stability had been negatively impacted by their vasculitis diagnosis. Fatigue was commonly reported. Work disabled patients were significantly more likely to be obese and less likely to have completed a tertiary education. Work disabled patients tended to be older, myeloperoxidase-antineutrophil cytoplasmic antibody positive, and have renal involvement and lung involvement.
A proportion of people living with AAV in Australia experience a decline in employment and an increase in work disability when living with this condition.
尽管抗中性粒细胞胞浆抗体相关性血管炎（AAV）最常影响老年人，但许多患者在其最具生产力的工作年龄阶段发病。本研究旨在调查 AAV 对澳大利亚工作年龄患者队列的就业和工作残疾的影响。
在澳大利亚墨尔本的血管炎诊所就诊的患者除了填写工作生产力和活动障碍问卷：特定健康问题外，还完成了一份就业调查问卷。
47 名应答者的平均年龄为 47.8±11.9 岁（范围 22-63 岁），中位疾病病程为 60 个月（范围 10.2-318.5 个月）。目前有 68.1%的人就业，但在诊断时就业的 20.6%的应答者不再工作，10.6%的人自诊断以来工作时间显著减少。有 12.7%的人依赖残疾支持养恤金。工作残疾率为 23.4%。许多参与者认为自己工作能力受损（41.9%），过去一周有 10.1%的人缺勤。此外，44.7%的应答者报告称，血管炎诊断对他们的财务稳定产生了负面影响。疲劳是常见的报告症状。工作残疾患者肥胖的可能性明显更高，而完成高等教育的可能性较低。工作残疾患者往往年龄较大，髓过氧化物酶-抗中性粒细胞胞浆抗体阳性，且有肾脏和肺部受累。
在澳大利亚，一部分患有 AAV 的人在患病期间就业下降，工作残疾增加。
