Tarquini B, Cavallini V, Cariddi A, Checchi M, Sorice V, Cecchettin M
Department of Medicine, University of Florence, Italy.
Chronobiol Int. 1988;5(2):149-52. doi: 10.3109/07420528809079555.
In young healthy subjects salmon calcitonin (SCT), intranasally administered, increased in serum as a function of the drug administration time. The serum concentration of a 400 IU SCT dose monitored 10 min after dosing was statistically more significant when inhaled at 0000 than at other, more conventional, administration times (morning or evening). Following dosing at certain times during the day, the serum SCT was less or even questionable with the dose and under the study conditions selected. Dosing without consideration of timing may lead to reduced effect or lack of effect or perhaps ambiguity or controversy regarding the possible circumstance of a "non-absorbent subject". The circadian frequency appears to be a critical determinant of intranasal SCT absorption suggesting administration time to be an important factor in the cost/benefit ratio without the unpleasant side effects sometimes experienced through parenteral routes.
在年轻健康受试者中，经鼻内给药的鲑鱼降钙素（SCT），其血清浓度随给药时间而增加。给药后10分钟监测的400 IU SCT剂量的血清浓度，在00:00吸入时在统计学上比在其他更常规的给药时间（早晨或晚上）更显著。在一天中的某些时间给药后，在所选择的剂量和研究条件下，血清SCT较低甚至可疑。不考虑给药时间可能会导致效果降低或无效，或者可能导致关于“吸收不良受试者”情况的模糊或争议。昼夜节律似乎是鼻内SCT吸收的关键决定因素，这表明给药时间是成本效益比中的一个重要因素，且不会出现有时通过肠胃外途径所经历的不良副作用。
