Dhandha S K
Department of Anesthesiology, Children's Hospital, Detroit, Michigan 48201.
Can J Anaesth. 1988 Jul;35(4):425-7. doi: 10.1007/BF03010868.
The use of dantrolene to reverse severe unexplained postanaesthetic muscle rigidity in a previously "healthy" 13-year-old male is described. Anaesthesia was induced with thiopentone. After intubation with pancuronium, the patient had an entirely uneventful nitrous oxide, oxygen and halothane anaesthetic. Immediately following reversal of the relaxant, the patient developed generalized muscle tightness and rigidity involving the trunk and extremities. This was prolonged and severe enough to interfere with adequate ventilation. The patient also had a prolonged recovery from the anaesthetic. After ruling out malignant hyperthermia and some other causes of rigidity, a tentative diagnosis of myotonia was made. The symptoms responded to IV dantrolene in a total dose of 2.0 mg.kg-1. Further testing failed to establish a definite diagnosis. Dantrolene could be a useful drug in treating such unexplained muscle rigidity.
本文描述了使用丹曲林治疗一名既往“健康”的13岁男性严重不明原因的麻醉后肌肉强直。麻醉诱导使用硫喷妥钠。使用泮库溴铵插管后，患者在氧化亚氮、氧气和氟烷麻醉过程中完全平稳。肌松药逆转后，患者立即出现全身性肌肉紧绷和强直，累及躯干和四肢。这种情况持续时间长且严重，足以干扰充分通气。患者麻醉恢复也延迟。排除恶性高热和其他一些导致强直的原因后，初步诊断为肌强直。症状对静脉注射总量为2.0mg/kg的丹曲林有反应。进一步检查未能明确诊断。丹曲林可能是治疗此类不明原因肌肉强直的有用药物。
