临床质谱方法在多发性骨髓瘤和淀粉样变性中的应用。

Clinical Mass Spectrometry Approaches to Myeloma and Amyloidosis.

机构信息

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

出版信息

Clin Lab Med. 2021 Jun;41(2):203-219. doi: 10.1016/j.cll.2021.03.003. Epub 2021 Apr 24.

DOI:10.1016/j.cll.2021.03.003

PMID:34020760

Abstract

The diagnosis of myeloma and other plasma cell disorders has traditionally been done with the aid of electrophoretic methods, whereas amyloidosis has been characterized by immunohistochemistry. Mass spectrometry has recently been established as an alternative to these traditional methods and has been proved to bring added benefit for patient care. These newer mass spectrometry-based methods highlight some of the key advantages of modern proteomic methods and how they can be applied to the routine care of patients.

摘要

传统上，多发性骨髓瘤和其他浆细胞疾病的诊断是借助电泳方法进行的，而淀粉样变性则通过免疫组织化学进行特征描述。质谱分析最近已被确立为这些传统方法的替代方法，并已被证明可为患者护理带来额外的益处。这些基于质谱的新技术突出了现代蛋白质组学方法的一些关键优势，以及它们如何应用于患者的常规护理。