Shvero J, Hadar T, Segal K, Abraham A, Sidi J
Department of Otolaryngology and Head and Neck Surgery, Beilinson Medical Center, Petah Tiqva, Israel.
Clin Otolaryngol Allied Sci. 1988 Jun;13(3):235-7. doi: 10.1111/j.1365-2273.1988.tb01125.x.
Between the years 1960 and 1981, 21 patients with the diagnosis of carcinoma in situ of the vocal cords were treated in the ENT department of Beilinson Medical Center. All 21 patients received initial irradiation therapy, identical to patients with invasive squamous cell carcinoma--7200 rads Co60 tumour dose. No patient died as a result of tumour. One patient had local recurrence of invasive carcinoma after 3 years and subsequently underwent total laryngectomy. One patient died after 15 years as a result of myocardial infarction. It is important to mention that 20 patients (95.2%) were free of tumour during a follow-up of 4-25 years (mean 11 years). This study shows that radiotherapy is a highly effective method of management for carcinoma in situ of the glottic region.
1960年至1981年间，21例被诊断为声带原位癌的患者在贝林森医疗中心耳鼻喉科接受治疗。所有21例患者均接受了初始放疗，放疗方式与浸润性鳞状细胞癌患者相同——肿瘤剂量为7200拉德钴60。没有患者因肿瘤死亡。1例患者在3年后出现浸润性癌局部复发，随后接受了全喉切除术。1例患者在15年后因心肌梗死死亡。需要指出的是，20例患者（95.2%）在4至25年（平均11年）的随访期间无肿瘤复发。本研究表明，放疗是声门区原位癌的一种高效治疗方法。
