米多君，一种口服α-1 肾上腺素能受体激动剂，成功治疗新生儿难治性先天性乳糜性胸腔积液和腹水。

Midodrine, an Oral Alpha-1 Adrenoreceptor Agonist, Successfully Treated Refractory Congenital Chylous Pleural Effusion and Ascites in a Neonate.

机构信息

Department of Pediatrics, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

出版信息

Chest. 2021 Apr;159(4):e189-e191. doi: 10.1016/j.chest.2020.10.071. Epub 2021 Apr 6.

DOI:10.1016/j.chest.2020.10.071

PMID:34022016

Abstract

A trisomy 21 neonate presented with congenital chylous pleural effusion and ascites that was refractory to conventional pharmacotherapy. Midodrine, an oral alpha-1-adrenoreceptor agonist, achieved remission of chylous effusion without any adverse effects. To the best of our knowledge, this is the first neonatal case of successful management of congenital chylous pleural effusion and ascites with midodrine.

摘要

一名 21 三体综合征新生儿出现先天性乳糜性胸腔积液和腹水，对常规药物治疗无反应。米多君，一种口服的α-1 肾上腺素能受体激动剂，成功地缓解了乳糜性渗出液，没有任何不良反应。据我们所知，这是首例使用米多君成功治疗先天性乳糜性胸腔积液和腹水的新生儿病例。