Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.
Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China.
Neurosci Lett. 2021 Jun 21;756:135965. doi: 10.1016/j.neulet.2021.135965. Epub 2021 May 19.
Neuropathic pain (NP) is caused by direct or indirect damage to the nervous system and is a common symptom of many diseases. The mechanisms underlying the onset and persistence of NP are unclear. Therefore, research concerning these mechanisms has become an important focus in the medical field. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family of signaling molecules. BDNF is an important regulator of neuronal development, synaptic transmission, and cellular and synaptic plasticity, which are essential for nerve maintenance and repair. However, BDNF is upregulated in the spinal dorsal horn and can promote NP by activating glial cells, reducing inhibitory functions and enhancing excitement after nociceptive stimulation. This review considers the relationship between NP and BDNF signaling in the spinal dorsal horn and discusses potentially related pathological mechanisms.
神经病理性疼痛（NP）是由神经系统的直接或间接损伤引起的，是许多疾病的常见症状。NP 发作和持续的机制尚不清楚。因此，研究这些机制已成为医学领域的一个重要焦点。脑源性神经营养因子（BDNF）是神经营养因子家族信号分子的一员。BDNF 是神经元发育、突触传递以及细胞和突触可塑性的重要调节剂，这些对于神经的维持和修复至关重要。然而，BDNF 在脊髓背角中上调，通过激活神经胶质细胞，在伤害性刺激后减少抑制功能并增强兴奋，从而促进 NP。本综述考虑了脊髓背角中 NP 与 BDNF 信号之间的关系，并讨论了可能相关的病理机制。
