Lewiecki E Michael
New Mexico Clinical Research & Osteoporosis Center, 300 Oak Street Northeast, Albuquerque, NM 87106, USA.
Endocrinol Metab Clin North Am. 2021 Jun;50(2):299-317. doi: 10.1016/j.ecl.2021.03.008. Epub 2021 Apr 28.
A bone fractures when a force applied to it exceeds its strength. Assessment of bone strength is an important component in determining the risk of fracture and guiding treatment decisions. Dual-energy X-ray absorptiometry is used to diagnosis osteoporosis, estimate fracture risk, and monitor changes in bone density. Fracture risk algorithms provide enhanced fracture risk predictability. Advanced technologies with computed tomography (CT) and MRI can measure parameters of bone microarchitecture. Mathematical modeling using CT data can evaluate the behavior of bone structures in response to external loading. Microindentation techniques directly measure the strength of outer bone cortex.
当施加于骨骼的力超过其强度时，骨骼就会发生骨折。评估骨骼强度是确定骨折风险和指导治疗决策的重要组成部分。双能X线吸收法用于诊断骨质疏松症、估计骨折风险以及监测骨密度变化。骨折风险算法可提高骨折风险的可预测性。计算机断层扫描（CT）和磁共振成像（MRI）等先进技术能够测量骨微结构参数。利用CT数据进行的数学建模可以评估骨结构在外部负荷作用下的行为。微压痕技术可直接测量骨皮质外层的强度。
