Whittington Hospital, Magdala Avenue, Highgate, London, N19 5NF, UK.
Department of Plastic Surgery, Sandwell General Hospital, Lyndon, West Bromwich, West Midlands, B71 4HJ, UK.
J Plast Reconstr Aesthet Surg. 2021 Jul;74(7):1610-1614. doi: 10.1016/j.bjps.2021.03.125. Epub 2021 Apr 22.
Hyaluronidase is a family of enzymes that degrade hyaluronic acid (HA). It is found to increase vascular permeability and temporarily disrupt the extracellular matrix, promoting diffusion of substances through tissues. Alongside its applications in ophthalmology, obstetrics and gynaecology, musculoskeletal medicine, radiology and drug and fluid administration, hyaluronidase has a number of roles in the field of plastic surgery. The popularity of HA fillers in recent years has led to an increase in the usage of hyaluronidase in the treatment of filler-related complications. The purpose of this article is to review the current and future uses of hyaluronidase within the field of plastic surgery. Hyaluronidase is used as an adjunct to local anaesthetics in skin infiltration, skin graft harvesting, tumescent analgesia, managing complications of dermal fillers, treatment of extravasation injury, prevention and management of oedema, treatment of ganglion and management of scars. However, it has some limitations. Hyaluronidase is known to interact with a number of common medications. Several case reports also highlight the risk of allergic reaction to the substance. Although rare and usually mild, hyaluronidase has the potential to cause anaphylaxis. Other adverse effects include bruising and swelling. Overall, hyaluronidase appears to be a very safe, cheap and effective medication for a variety of uses in the field of plastic surgery and beyond.
透明质酸酶是一组能够降解透明质酸 (HA) 的酶。它被发现可以增加血管通透性并暂时破坏细胞外基质，促进物质通过组织扩散。除了在眼科、妇产科、肌肉骨骼医学、放射学以及药物和液体给药中的应用外，透明质酸酶在整形外科学领域还有许多作用。近年来，透明质酸填充物的普及导致了在治疗填充物相关并发症中使用透明质酸酶的增加。本文旨在综述透明质酸酶在整形外科学领域的当前和未来用途。透明质酸酶被用作局部麻醉剂在皮肤浸润、皮肤移植、肿胀镇痛、管理真皮填充物并发症、处理外渗损伤、预防和管理水肿、治疗神经节和管理疤痕中的辅助剂。然而，它也有一些局限性。透明质酸酶已知与许多常见药物相互作用。一些病例报告还强调了对该物质过敏反应的风险。尽管罕见且通常较轻，但透明质酸酶有可能引起过敏反应。其他不良反应包括瘀伤和肿胀。总的来说，透明质酸酶似乎是一种非常安全、廉价且有效的药物，可用于整形外科学领域及其他领域的多种用途。
