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稠合嘧啶（抗病毒化合物的结构类似物）合成中的迪莫思重排反应

The Dimroth Rearrangement in the Synthesis of Condensed Pyrimidines - Structural Analogs of Antiviral Compounds.

作者信息

Mamedov Vakhid А, Zhukova Nataliya А, Kadyrova Milyausha S

机构信息

Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, 8 Akademika Arbuzova St, Kazan, 420088 Russia.

出版信息

Chem Heterocycl Compd (N Y). 2021;57(4):342-368. doi: 10.1007/s10593-021-02913-7. Epub 2021 May 15.

DOI:10.1007/s10593-021-02913-7
PMID:34024912
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8121644/
Abstract

The review discusses the use of the Dimroth rearrangement in the synthesis of condensed pyrimidines which are key structural fragments of antiviral agents. The main attention is given to publications over the past 10 years. The bibliography includes 107 references.

摘要

该综述讨论了Dimroth重排在稠合嘧啶合成中的应用，稠合嘧啶是抗病毒药物的关键结构片段。主要关注过去10年的出版物。参考文献包括107篇。

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Tetrahedron Lett. 2017 Apr 12;58(15):1467-1469. doi: 10.1016/j.tetlet.2017.02.082.
9
A concise construction of 12H-benzo[4,5]thiazolo[2,3-b]quinazolin-12-ones via an unusual TBHP/NaCO promoted cascade oxidative cyclization and interrupted Dimroth rearrangement.通过一种不寻常的叔丁基过氧化氢/碳酸钠促进的级联氧化环化和中断的迪姆罗特重排反应简洁构建12H-苯并[4,5]噻唑并[2,3-b]喹唑啉-12-酮
Chem Commun (Camb). 2017 Jan 17;53(6):1056-1059. doi: 10.1039/c6cc09376k.
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Aminopurine and aminoquinazoline scaffolds for development of potential dengue virus inhibitors.用于开发潜在登革病毒抑制剂的氨基嘌呤和氨基喹唑啉支架
Eur J Med Chem. 2017 Jan 27;126:101-109. doi: 10.1016/j.ejmech.2016.10.008. Epub 2016 Oct 5.