血清尿酸与中风风险：一项剂量反应荟萃分析。
Serum uric acid and risk of stroke: a dose-response meta-analysis.
作者信息
Dong Yunan, Shi Han, Chen Xinxin, Fu Kailei, Li Jinwei, Chen Hanze, Teng Weiyu, Tian Li
机构信息
Department of Geriatrics, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Heping District, Shenyang 110004, China.
The First Clinical Department, China Medical University, No. 77, Puhe Road, Shenyang North Area, Shenyang, Liaoning Province, 110122, China.
出版信息
J Clin Biochem Nutr. 2021 May;68(3):221-227. doi: 10.3164/jcbn.20-94. Epub 2020 Oct 13.
The relationship between serum uric acid and risk of stroke is still controversial. Therefore, we conducted a meta-analysis based on the cohort study to explore the relationship between serum uric acid and risk of stroke, and further illuminate whether there is a linear or non-linear relationship between them. We manually searched the database including Cochrane, PubMed, Embase, Web of Science, and selected cohort studies focusing on the relationship between serum uric acid and stroke risk. Random effect model was used for statistical analysis. Twenty-one cohort studies involving 818,098 participants were included. The pooled relative risk for the high-vs-low categories was 1.22 (95% CI: 1.15-1.30). In addition, there was a non-linear dose-response relationship between uric acid and stroke risk. Serum uric acid was in the range of 3-5 mg/dl, with the lowest risk of stroke. In conclusion, high serum uric acid level increases the risk of stroke, with a non-linear dose-response relationship.
血清尿酸与中风风险之间的关系仍存在争议。因此，我们基于队列研究进行了一项荟萃分析，以探讨血清尿酸与中风风险之间的关系，并进一步阐明它们之间是否存在线性或非线性关系。我们手动检索了包括Cochrane、PubMed、Embase、Web of Science在内的数据库，并选择了关注血清尿酸与中风风险关系的队列研究。采用随机效应模型进行统计分析。纳入了21项涉及818,098名参与者的队列研究。高尿酸组与低尿酸组的合并相对风险为1.22（95%置信区间：1.15-1.30）。此外，尿酸与中风风险之间存在非线性剂量反应关系。血清尿酸水平在3-5mg/dl范围内时，中风风险最低。总之，高血清尿酸水平会增加中风风险，且存在非线性剂量反应关系。
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