Buksińska-Lisik Małgorzata, Kwasiborski Przemysław, Ryczek Robert, Lisik Wojciech, Mamcarz Artur
3rd Department of Internal Medicine and Cardiology, Medical University of Warsaw, 04-749 Warsaw, Poland.
Department of Cardiology and Internal Diseases, Regional Hospital in Miedzylesie, 04-749 Warsaw, Poland.
J Clin Med. 2022 Apr 26;11(9):2421. doi: 10.3390/jcm11092421.
Pancreas transplantation is considered a high-risk surgery with cardiovascular complications. Early detection of all potential cardiovascular risk factors can decrease the perioperative risk and improve the pancreas recipients' outcome. The present study aims to evaluate the association between serum uric acid (UA) levels and the prevalence of coronary artery disease (CAD) in patients eligible for pancreas transplantation. We prospectively enrolled 63 consecutive patients with type 1 diabetes (T1D) who underwent cardiological evaluation before pancreas transplantation in our center. Participants underwent clinical evaluation, laboratory assays, and coronary angiography. The median concentration of UA in patients with CAD was significantly higher than in participants without CAD (6.43 (4.93-7.26) vs. 4.41 (3.64-5.49) mg/dL, = 0.0002). We showed the positive correlation between UA concentration and systolic blood pressure, pulse pressure (PP) and triglycerides (r = 0.271, = 0.032; r = 0.327, = 0.009; r = 0.354, = 0.004, respectively). In a multivariate analysis, the concentration of UA (OR 2.044; 95% CI: 1.261-3.311, = 0.004) was independently associated with the prevalence of CAD in pancreas transplant candidates with T1D. We demonstrated that elevated UA levels were strongly associated with the high prevalence of CAD in pancreas transplant candidates with T1D. To stratify cardiovascular risk, the measurement of the UA concentration should be considered in all T1D patients qualified for pancreas transplantation.
胰腺移植被认为是一种存在心血管并发症的高风险手术。早期发现所有潜在的心血管危险因素可降低围手术期风险并改善胰腺移植受者的预后。本研究旨在评估血清尿酸（UA）水平与符合胰腺移植条件患者的冠状动脉疾病（CAD）患病率之间的关联。我们前瞻性地纳入了63例连续的1型糖尿病（T1D）患者，这些患者在我们中心接受了胰腺移植前的心脏评估。参与者接受了临床评估、实验室检测和冠状动脉造影。CAD患者的UA中位浓度显著高于无CAD的参与者（6.43（4.93 - 7.26）对4.41（3.64 - 5.49）mg/dL，P = 0.0002）。我们发现UA浓度与收缩压、脉压（PP）和甘油三酯之间呈正相关（r分别为0.271，P = 0.032；r = 0.327，P = 0.009；r = 0.354，P = 0.004）。在多变量分析中，UA浓度（OR 2.044；95% CI：1.261 - 3.311，P = 0.004）与T1D胰腺移植候选者中CAD的患病率独立相关。我们证明，UA水平升高与T1D胰腺移植候选者中CAD的高患病率密切相关。为了分层心血管风险，所有符合胰腺移植条件 的T1D患者都应考虑测量UA浓度。
