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砷中毒在急性早幼粒细胞白血病诱导治疗期间表现为大量水样腹泻。

Arsenic toxicity manifesting as profuse watery diarrhea during induction therapy for acute promyelocytic leukemia.

作者信息

Ott Ashley, Venkataraman Vinayak, Badran Yousef R, Goldman Rose, Spasic Smiljana, Vyas Darshali A, Amrein Philip, McAfee Steven, Brunner Andrew, Fathi Amir T, Narayan Rupa

机构信息

Department of Medicine Massachusetts General Hospital Boston MA USA.

Division of Gastroenterology Department of Medicine Massachusetts General Hospital Boston MA USA.

出版信息

Clin Case Rep. 2021 May 15;9(5):e04115. doi: 10.1002/ccr3.4115. eCollection 2021 May.

DOI:10.1002/ccr3.4115
PMID:34026155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8122218/
Abstract

Arsenic trioxide (ATO) is generally well tolerated for treatment of APL. We present a patient with severe watery diarrhea and pancreatitis thought to be due to ATO toxicity in the setting of obesity and acute kidney injury. Future studies evaluating ATO levels in patients experiencing toxicities may help guide dose modifications.

摘要

三氧化二砷（ATO）用于治疗急性早幼粒细胞白血病（APL）时通常耐受性良好。我们报告了一名患者，其出现严重水样腹泻和胰腺炎，考虑是在肥胖和急性肾损伤背景下由ATO毒性所致。未来评估发生毒性反应患者体内ATO水平的研究可能有助于指导剂量调整。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1977/8122218/cc3fa95f3031/CCR3-9-e04115-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1977/8122218/cc3fa95f3031/CCR3-9-e04115-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1977/8122218/cc3fa95f3031/CCR3-9-e04115-g001.jpg

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Metallomics. 2020 Mar 1;12(3):326-336. doi: 10.1039/c9mt00308h. Epub 2020 Mar 12.
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Multicenter evaluation of arsenic trioxide dosing in obese patients with low-intermediate risk acute promyelocytic leukemia.
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Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome.个体对砷诱导疾病的易感性：宿主遗传学、营养状况和肠道微生物群的作用。
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