Jacob T J, Humphry R C, Davies E G, Thompson G M
Department of Pharmacology, St. George's Hospital Medical School, London.
Eye (Lond). 1988;2 ( Pt 3):304-8. doi: 10.1038/eye.1988.57.
The proliferation of lens epithelial cells remaining attached to the capsule after extracapsular cataract extraction represents a potential cause of posterior capsule opacification. In view of the reported mitogenic effects of eye derived growth factors on lens epithelial cells in animal studies, we determined to establish whether the human retina produces a factor capable of inducing a similar response in human lens epithelial (HLE) cells. We report that an extract of the human neural retina is capable of increasing the proliferative capacity of HLE cells in culture by 50%. The possible mechanisms are discussed. The presence of such a growth factor in the human eye would have important consequences for the epithelial cells remaining after cataract surgery.
囊外白内障摘除术后，残留于晶状体囊膜上的晶状体上皮细胞增殖是后囊膜混浊的一个潜在原因。鉴于动物研究中报道的眼源性生长因子对晶状体上皮细胞的促有丝分裂作用，我们决定确定人类视网膜是否产生一种能够在人晶状体上皮（HLE）细胞中诱导类似反应的因子。我们报告称，人神经视网膜提取物能够使培养中的HLE细胞增殖能力提高50%。文中讨论了可能的机制。人眼中存在这种生长因子将对白内障手术后残留的上皮细胞产生重要影响。
