Ophthalmology Department, Hospital De Braga, Braga, Portugal.
Ophthalmology Department, Hospital Lusíadas, Porto, Portugal.
Semin Ophthalmol. 2022 Feb 17;37(2):153-157. doi: 10.1080/08820538.2021.1931357. Epub 2021 May 23.
To compare the efficacy and safety of foveal and extrafoveal half-dose photodynamic therapy (HD-PDT) for chronic Central Serous Chorioretinopathy (cCSC).
This retrospective, cohort study included cCSC eyes submitted to HD-PDT on foveal (F) or extrafoveal (E) areas. Patients were evaluated at baseline and 12 weeks after treatment for best corrected visual acuity (BCVA) and the following spectral-domain optical coherence tomography (SD-OCT) subfoveal parameters: central macular thickness (CMT), outer nuclear layer, external limiting membrane, ellipsoid zone, interdigitation zone, choroidal thickness and subretinal fluid (SRF).
F group comprised 33 eyes (47.1%) and E group comprised 37 eyes (52.9%). Both groups showed an improvement of BCVA after HD-PDT with no significant differences in final BCVA ( = .41). CMT and SRF showed a significant improvement after HD-PDT in both groups, but the rate of disruption of the external retinal layers remained stable. During follow-up, SD-OCT parameters and the rate of anatomical success showed no significant differences regarding the treatment location. No major sequelae were noticed.
Foveal and extrafoveal applications of HD-PDT for cCSC showed comparable efficacy and safety.
比较黄斑中心凹和中心凹外半剂量光动力疗法（HD-PDT）治疗慢性中心性浆液性脉络膜视网膜病变（cCSC）的疗效和安全性。
这是一项回顾性队列研究，纳入了接受 HD-PDT 治疗的 cCSC 眼，治疗部位为黄斑中心凹（F）或中心凹外（E）区域。治疗后 12 周，对患者进行最佳矫正视力（BCVA）和以下频域光相干断层扫描（SD-OCT）亚区参数评估：中心黄斑厚度（CMT）、外核层、外界膜、椭圆体带、外丛状层、脉络膜厚度和视网膜下液（SRF）。
F 组包括 33 只眼（47.1%），E 组包括 37 只眼（52.9%）。两组患者在 HD-PDT 后均有 BCVA 改善，最终 BCVA 无显著差异（ =.41）。CMT 和 SRF 在两组患者中均在 HD-PDT 后得到显著改善，但外视网膜层的破坏率保持稳定。在随访期间，SD-OCT 参数和解剖学成功率在治疗部位方面没有显著差异。未发现明显的后遗症。
cCSC 的黄斑中心凹和中心凹外应用 HD-PDT 具有相似的疗效和安全性。
