Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland.
National Children's Research Centre, Dublin, Ireland.
FEBS J. 2022 Aug;289(15):4355-4370. doi: 10.1111/febs.16030. Epub 2021 Jun 10.
It is essential to relate the biology of acute leukaemia to normal blood cell development. In this review, we discuss how modern models of haematopoiesis might inform approaches to diagnosis and management of immature leukaemias, with a specific focus on T-lymphoid and myeloid cases. In particular, we consider whether next-generation analytical tools could provide new perspectives that could improve our understanding of immature blood cancer biology.
必须将急性白血病的生物学与正常血细胞的发育联系起来。在这篇综述中，我们讨论了造血的现代模型如何为不成熟白血病的诊断和治疗方法提供信息，特别是关注 T 淋巴细胞性和髓性病例。我们特别考虑下一代分析工具是否可以提供新的视角，从而增进我们对不成熟血液癌症生物学的理解。
