Portolés M, Sanchis R, Guerri C
Instituto de Investigaciones Citológicas de la Caja de Ahorros de Valencia, Spain.
Horm Metab Res. 1988 May;20(5):267-70. doi: 10.1055/s-2007-1010812.
Maternal ingestion of alcohol appears to cause a pattern of congenital anomalies with a reduction of pre- and postnatal growth in the offspring. In order to study the possible implication of thyroid function in the effects of pre- and/or postnatal exposure to alcohol, we have studied serum thyroxine (T4) and triiodothyronine (T3) levels in rats from alcohol-fed mothers during the postnatal period (0-50 days). Blood alcohol levels of ethanol-treated pregnant rats were approximately equal to 20-25 mM and their serum T4 levels were decreased, compared with the pair-fed controls, at 15 and 21 days of gestation. No significant changes were observed in T3 levels. Prenatal alcohol exposure was associated with a decrease in both T4 and T3 levels in pups at birth. Although T4 levels continued reduced in the 40-50 days of the postnatal period, no clear effects were observed on T3 levels during this time. Moreover, the more marked alterations were obtained when the offspring were postnatally and pre + postnatally exposed to alcohol. Significant decreases were found in both T4 and T3 levels following postnatal exposure, except at the 20-25th day when a marked but transient increase in T4 levels was observed. These results indicate that alcohol exposure disturbs the hypothalamo-pituitary-thyroid axis, as measured by T3 and T4 hormone levels, mainly when the rats are exposed during the postnatal period.
母亲摄入酒精似乎会导致一系列先天性异常，并使后代的出生前和出生后生长发育减缓。为了研究甲状腺功能在出生前和/或出生后暴露于酒精影响中的可能作用，我们研究了出生后时期（0 - 50天）来自酒精喂养母亲的大鼠的血清甲状腺素（T4）和三碘甲状腺原氨酸（T3）水平。与配对喂养的对照组相比，乙醇处理的怀孕大鼠在妊娠第15天和第21天的血酒精水平约为20 - 25 mM，其血清T4水平降低。T3水平未观察到显著变化。出生前暴露于酒精与幼崽出生时T4和T3水平的降低有关。虽然在出生后40 - 50天T4水平持续降低，但在此期间未观察到对T3水平有明显影响。此外，当后代在出生后以及出生前和出生后都暴露于酒精时，会出现更明显的变化。出生后暴露后，T4和T3水平均显著降低，但在第20 - 25天观察到T4水平有明显但短暂的升高。这些结果表明，以T3和T4激素水平衡量，酒精暴露会扰乱下丘脑 - 垂体 - 甲状腺轴，主要是在大鼠出生后暴露期间。
