Department of Pathology, Nowon Eulji Medical Center, Eulji University.
Department of Pathology, Uijeongbu Eulji University Medical Center, Eulji University, Gyeonggi-do.
Appl Immunohistochem Mol Morphol. 2021 Oct 1;29(9):685-692. doi: 10.1097/PAI.0000000000000948.
Programmed cell death 4 (PDCD4) is a tumor suppressor gene that inhibits tumor progression, invasion, and metastasis. Decreased PDCD4 expression is associated with poor prognosis in various types of cancers. We evaluated PDCD4 expression and its clinicopathologic correlation, including patient survival, in 289 surgically resected colorectal cancers. Low nuclear PDCD4 expression was identified in 177 (61.2%) cases and was associated with large tumor size, high pT classification, and the presence of lymphovascular and perineural invasion. The 5-year survival rate of patients with low nuclear PDCD4 expression was significantly lower than that of patients with high expression (72.2% vs. 93.3%, P<0.001). American Joint Committee on Cancer stage II and III colorectal cancer patients with low nuclear PDCD4 expression (76.9% and 67.2%, respectively) showed significantly worse overall survival than those with high expression (100% and 92.9%, P=0.002 and 0.032, respectively). Low nuclear PDCD4 expression was an independent poor prognostic factor in colorectal cancer patients (hazard ratio=3.556; 95% confidence interval, 1.739-7.271; P=0.001). Our study suggests that low PDCD4 expression is associated with aggressive behavior and can be used as a prognostic indicator of colorectal cancer patients.
程序性细胞死亡因子 4（PDCD4）是一种肿瘤抑制基因，可抑制肿瘤的进展、侵袭和转移。PDCD4 表达降低与多种类型癌症的不良预后相关。我们评估了 289 例手术切除的结直肠癌中 PDCD4 的表达及其与临床病理特征的相关性，包括患者的生存情况。177 例（61.2%）病例存在低核 PDCD4 表达，与肿瘤较大、pT 分级较高、存在血管淋巴管侵犯和神经周围侵犯有关。低核 PDCD4 表达患者的 5 年生存率明显低于高表达患者（72.2%比 93.3%，P<0.001）。美国癌症联合委员会（AJCC）分期 II 和 III 期结直肠癌患者中，低核 PDCD4 表达患者的总生存率明显低于高表达患者（分别为 76.9%和 67.2%，P=0.002 和 0.032）。低核 PDCD4 表达是结直肠癌患者的独立不良预后因素（风险比=3.556；95%置信区间，1.739-7.271；P=0.001）。本研究表明，低 PDCD4 表达与侵袭性行为相关，可作为结直肠癌患者的预后指标。
