College of Science, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai, 200093, PR China.
Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No.197, Rui Jin Er Road, Shanghai, 200025, PR China.
Colloids Surf B Biointerfaces. 2021 Sep;205:111852. doi: 10.1016/j.colsurfb.2021.111852. Epub 2021 May 17.
In this research, MnO/IrO nanoplatform was one-step synthesized from the heat-induced oxidation-reduction between potassium permanganate and iridium chloride and modified with polyvinylpyrrolidone (PVP) on the surface to obtain MnO/IrO-PVP nanoparticles (MIP NPs) with excellent colloidal stability of biocompatibility. Then, the photosensitizer Chlorin e6 (Ce6) was loaded onto the surface of MIP NPs. The IrO can efficiently transform the 808 nm near-infrared laser into heat with a photothermal conversion of 27.57 % for tumor photothermal therapy. Interestingly, the MnO can not only react with the redundant H and realize the magnetic resonance imaging of the tumor but also catalytic the decomposition of HO in the tumor to generate O and relieve the hypoxia status of the tumor. The in-situ formed O can promote the production of cancer cell-toxic singlet oxygens (O) under the irradiation of 660 nm laser and boost the tumor photodynamic therapy efficiency. Moreover, it was found that PVP can fall off from the MIP NPs to increase their accumulation in the tumor. Such a MIP/Ce6-based nanoplatform which plays the synergism with tumor microenvironment shows promising potential for the combined photo-therapy of the tumor.
在这项研究中，MnO/IrO 纳米平台是通过高锰酸钾和氯化铱之间的热诱导氧化还原一步合成的，并在表面用聚乙烯吡咯烷酮（PVP）进行修饰，得到具有优异胶体稳定性和生物相容性的 MnO/IrO-PVP 纳米颗粒（MIP NPs）。然后，光敏剂 Chlorin e6（Ce6）被负载到 MIP NPs 的表面。IrO 可以有效地将 808nm 近红外激光转化为热量，光热转换效率为 27.57%，用于肿瘤光热治疗。有趣的是，MnO 不仅可以与多余的 H 反应，实现肿瘤的磁共振成像，还可以催化肿瘤中 HO 的分解，生成 O 并缓解肿瘤的缺氧状态。在 660nm 激光照射下，原位生成的 O 可以促进癌细胞毒性单线态氧（1O2）的产生，从而提高肿瘤光动力治疗的效率。此外，还发现 PVP 可以从 MIP NPs 上脱落，从而增加其在肿瘤中的积累。这种基于 MIP/Ce6 的纳米平台与肿瘤微环境协同作用，为肿瘤的联合光疗展示了广阔的应用前景。
