新生儿感染与长期神经发育结局的关系。
Association of Infection in Neonates and Long-Term Neurodevelopmental Outcome.
机构信息
Division of Neonatology, Department of Pediatrics, Emory University School of Medicine & Children's Healthcare of Atlanta, 2015 Uppergate Drive, Office #318, Atlanta, GA 30322, USA.
Division of Neonatology, Department of Pediatrics, Emory University School of Medicine & Children's Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA 30322, USA.
出版信息
Clin Perinatol. 2021 Jun;48(2):251-261. doi: 10.1016/j.clp.2021.03.001.
Abstract
Perinatal and neonatal infection and associated inflammatory response may adversely affect brain development and lead to neurodevelopmental impairment. Factors that predict the risk of infection and subsequent adverse outcomes have been identified but substantial gaps remain in identifying mechanisms and interventions that can alter outcomes. This article describes the current epidemiology of neonatal sepsis, the pathogenesis of brain injury with sepsis, and the reported long-term neurodevelopment outcomes among survivors.
摘要
围产期和新生儿感染及相关炎症反应可能对大脑发育产生不利影响，并导致神经发育障碍。已经确定了预测感染风险和随后不良结局的因素，但在确定可改变结局的机制和干预措施方面仍存在很大差距。本文描述了新生儿败血症的当前流行病学、败血症性脑损伤的发病机制以及幸存者报告的长期神经发育结局。
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