Microglia: Newly discovered complexity could lead to targeted therapy for neonatal white matter injury and dysmaturation.
作者信息
Volpe J J
机构信息
Department of Neurology, Harvard Medical School, Boston, MA.
Department of Pediatric Newborn Medicine, Harvard Medical School, Boston, MA.
出版信息
J Neonatal Perinatal Med. 2019;12(3):239-242. doi: 10.3233/NPM-190303.
Abstract
摘要
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本文引用的文献
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Dysmaturation of Premature Brain: Importance, Cellular Mechanisms, and Potential Interventions.早产儿脑发育不良：重要性、细胞机制及潜在干预措施。
Pediatr Neurol. 2019 Jun;95:42-66. doi: 10.1016/j.pediatrneurol.2019.02.016. Epub 2019 Feb 27.
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The role of microRNAs in newborn brain development and hypoxic ischaemic encephalopathy.微小 RNA 在新生儿脑发育和缺氧缺血性脑病中的作用。
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MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway.miR-124 富集的外泌体通过抑制 TLR4 通路促进创伤性脑损伤后小胶质细胞的 M2 极化和增强海马神经发生。
Neurochem Res. 2019 Apr;44(4):811-828. doi: 10.1007/s11064-018-02714-z. Epub 2019 Jan 9.
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Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.单细胞 RNA 测序技术揭示了小鼠整个生命周期及损伤大脑中小胶质细胞的复杂细胞状态变化。
Immunity. 2019 Jan 15;50(1):253-271.e6. doi: 10.1016/j.immuni.2018.11.004. Epub 2018 Nov 21.
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Microglia and the Brain: Complementary Partners in Development and Disease.小胶质细胞与大脑：发育和疾病中的互补伙伴。
Annu Rev Cell Dev Biol. 2018 Oct 6;34:523-544. doi: 10.1146/annurev-cellbio-100616-060509. Epub 2018 Aug 8.
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Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury.基于树突状聚合物的母体疗法治疗炎症诱导的早产及围生期脑损伤。
Sci Rep. 2017 Jul 21;7(1):6106. doi: 10.1038/s41598-017-06113-2.
7
Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic-ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia.新生鼠缺氧缺血性脑损伤后树突状聚合物-药物在海马不同细胞类型中的摄取：损伤、小胶质细胞激活和低温的影响。
Nanomedicine. 2017 Oct;13(7):2359-2369. doi: 10.1016/j.nano.2017.06.014. Epub 2017 Jun 30.
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Confusions in Nomenclature: "Periventricular Leukomalacia" and "White Matter Injury"-Identical, Distinct, or Overlapping?命名中的困惑：“脑室周围白质软化症”与“白质损伤”——相同、不同还是重叠？
Pediatr Neurol. 2017 Aug;73:3-6. doi: 10.1016/j.pediatrneurol.2017.05.013. Epub 2017 May 24.
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Reactive Astrocytes: Production, Function, and Therapeutic Potential.反应性星形胶质细胞：产生、功能和治疗潜力。
Immunity. 2017 Jun 20;46(6):957-967. doi: 10.1016/j.immuni.2017.06.006.
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Neurotoxic reactive astrocytes are induced by activated microglia.神经毒性反应性星形胶质细胞由活化的小胶质细胞诱导产生。
Nature. 2017 Jan 26;541(7638):481-487. doi: 10.1038/nature21029. Epub 2017 Jan 18.
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