Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of Radiology, Malaysia.
Universiti Kebangsaan Malaysia, Faculty of Health Sciences, Therapeutic and Investigative Studies, Centre for Diagnostic, Malaysia.
Med J Malaysia. 2021 May;76(3):291-297.
Risk factors for cardiovascular disease (CVD) have been increasingly implicated in the development of dementia but little is known about the effects in a Malaysian population. We aimed to determine the interaction between sociodemographic and CVD risk factors among the dementia and mild cognitive impairment (MCI) patients in Malaysia.
A cross-sectional study was conducted in the memory clinic at Hospital Kuala Lumpur (HKL). Medical records data from 2014 to 2019 were extracted. Mini Mental State Examination (MMSE) test was used to assess the neurocognitive function of patients.
A total of 298 patients (30 MCI, and 268 dementia) were evaluated, with dementia patients consisting of 78 Alzheimer's disease (AD), 93 Vascular dementia (VaD), 94 Mixed dementia, 2 early-onset Alzheimer's disease (EOAD) and 1 Logopenic Progressive Aphasia type of AD (LPA). MCI and dementia were significantly associated with a history of CVD, particularly stroke (p=0.023).
Given that stroke significantly predicted the risk of developing vascular dementia among the patients in a central Malaysian population, lifestyle modifications are recommended to alleviate these risk factors of CVD.
心血管疾病 (CVD) 的风险因素已被越来越多地认为与痴呆的发生有关，但在马来西亚人群中，其影响知之甚少。我们旨在确定马来西亚痴呆和轻度认知障碍 (MCI) 患者的社会人口学和 CVD 风险因素之间的相互作用。
这是在吉隆坡医院 (HKL) 的记忆诊所进行的横断面研究。从 2014 年至 2019 年提取了病历数据。使用简易精神状态检查 (MMSE) 测试评估患者的神经认知功能。
共评估了 298 名患者（30 名 MCI 和 268 名痴呆），其中痴呆患者包括 78 名阿尔茨海默病 (AD)、93 名血管性痴呆 (VaD)、94 名混合性痴呆、2 名早发性阿尔茨海默病 (EOAD) 和 1 名失语法性进行性失语症型 AD (LPA)。MCI 和痴呆与 CVD 病史显著相关，尤其是中风 (p=0.023)。
鉴于中风显著预测了马来西亚中部人群中血管性痴呆患者发生血管性痴呆的风险，建议进行生活方式改变以减轻这些 CVD 风险因素。
