Universiti Sains Malaysia, School of Medical Sciences, Department of Physiology, Kubang Kerian, Kelantan, Malaysia.
Universiti Sains Malaysia, School of Medical Sciences, Department of Surgery, Kubang Kerian, Kelantan, Malaysia.
Med J Malaysia. 2021 May;76(3):375-381.
Inflammation plays a central role in the pathogenesis of cardiovascular events. The lack of exercise among Malaysians and the increasing cardiovascular diseases among young men are of concern. The aim of this study was to evaluate the reducing of inflammation by measuring C-Reactive protein (CRP), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α).
A total of 70 young men (20 - 40 years) who were sedentary, achieving less than 5,000 steps/day in casual walking with 2 or more cardiovascular risk factors were recruited in Institute of Vocational Skills for Youth (IKBN Hulu Langat). Subjects were randomly assigned to a control group (CG) (n=34; no change in walking) and pedometer group (PG) (n=36; minimum target: 8,000 steps/day). All parameter was measured at baseline, at 6 weeks and after 12 weeks.
At post intervention, the CG step counts were similar (4983 ± 366vs 5697 ± 407steps/day). The PG significant increased step count from 4996 ± 805 to 10,128 ±511 steps/day (p<0.001). The PG showed significant improvement in anthropometric variables and lipid (time and group effect p<0.001). After intervention, CRP, IL-6 and TNF- α were significantly reduced for time and group effect (p<0.001). However, no changes were seen in CG.
The pedometer-based walking programme improved health status in terms of improving inflammation and arterial stiffness.
炎症在心血管事件的发病机制中起着核心作用。马来西亚人缺乏运动，而年轻男性的心血管疾病发病率不断上升，令人担忧。本研究旨在通过测量 C 反应蛋白（CRP）、白细胞介素 6（IL-6）和肿瘤坏死因子-α（TNF-α）来评估炎症的减少。
共招募了 70 名久坐不动的年轻男性（20-40 岁），他们在日常散步中每天的步数少于 5000 步，且有 2 个或更多心血管危险因素。受试者被随机分配到对照组（CG）（n=34；不改变步行方式）和计步器组（PG）（n=36；最低目标：每天 8000 步）。所有参数均在基线、6 周和 12 周时进行测量。
干预后，CG 的步数相似（4983±366 与 5697±407 步/天）。PG 的步数从 4996±805 显著增加到 10128±511 步/天（p<0.001）。PG 在人体测量变量和血脂方面有显著改善（时间和组间效应 p<0.001）。干预后，CRP、IL-6 和 TNF-α 的时间和组间效应均显著降低（p<0.001）。然而，CG 中没有观察到变化。
基于计步器的步行计划改善了炎症和动脉僵硬状况，从而提高了健康水平。
