Marshall University, Huntington, WV, USA.
J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211017423. doi: 10.1177/23247096211017423.
Plasmablastic lymphoma (PBL) is a very rare disease and it is usually considered a human immunodeficiency virus (HIV)-related B-cell lymphoma that carries a poor prognosis. It mostly involves the oral cavity, lungs, nasal cavity, gastrointestinal tract, lymph node, and skin. Therapeutic regimens like dose-adjusted etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone (DA-EPOCH) have shown better results in these aggressive lymphomas. We report a rare case of PBL in an HIV-negative patient who presented to the clinic with a complaint of left testicular swelling for 3 months. Ultrasound showed an enlarged left testicle. He underwent a left orchiectomy and the pathology showed PBL with involvement of the spermatic cord margin. Positron emission tomography scan showed hypermetabolic mediastinal and hilar lymph nodes. He was started on DA-EPOCH but showed no response. Accordingly, salvage therapy with bortezomib in addition to ifosfamide carboplatin and etoposide (B-ICE) chemotherapy was initiated with remarkable response. Several other regimens can be used in the refractory setting; however, the evidence is mostly based on retrospective analysis.
浆母细胞淋巴瘤（PBL）是一种非常罕见的疾病，通常被认为是与人类免疫缺陷病毒（HIV）相关的 B 细胞淋巴瘤，预后不良。它主要涉及口腔、肺部、鼻腔、胃肠道、淋巴结和皮肤。在这些侵袭性淋巴瘤中，剂量调整依托泊苷、长春新碱、多柔比星、环磷酰胺和泼尼松（DA-EPOCH）等治疗方案显示出更好的效果。我们报告了一例罕见的 HIV 阴性患者的 PBL 病例，该患者因左睾丸肿胀 3 个月就诊。超声显示左侧睾丸增大。他接受了左侧睾丸切除术，病理显示 PBL 累及精索边缘。正电子发射断层扫描显示纵隔和肺门淋巴结高代谢。他开始接受 DA-EPOCH 治疗，但没有反应。因此，开始使用硼替佐米联合异环磷酰胺、卡铂和依托泊苷（B-ICE）化疗进行挽救治疗，反应显著。在难治性疾病中还可以使用其他几种方案，但这些证据主要基于回顾性分析。
