Ochsendorf F R, Runne U
Zentrum der Dermatologie und Venerologie, J.W. Goethe-Universität Frankfurt/M.
Hautarzt. 1988 Jun;39(6):341-2.
Decisive for the development of chloroquine retinopathy is not the total cumulative dose. Recent findings indicate that retinopathy develops if daily dosages are too high. Therefore, daily dosages of 4 mg chloroquine/kg ideal body weight and 6.5 mg hydroxychloroquine/kg body weight, respectively, should not be exceeded. If these maximum daily dosages are observed, long-term therapy over periods of months or even years seems to be safe.
决定氯喹视网膜病变发展的并非总累积剂量。最近的研究结果表明，如果每日剂量过高，就会发生视网膜病变。因此，氯喹每日剂量不应超过4毫克/千克理想体重，羟氯喹每日剂量不应超过6.5毫克/千克体重。如果遵守这些每日最大剂量，数月甚至数年的长期治疗似乎是安全的。
