[氯喹视网膜病变：通过监测每日最大剂量可预防]
[Chloroquine retinopathy: preventable by monitoring the maximum daily dose].
作者信息
Ochsendorf F R, Runne U
机构信息
Zentrum der Dermatologie und Venerologie, J.W. Goethe-Universität Frankfurt/M.
出版信息
Hautarzt. 1988 Jun;39(6):341-2.
PMID:3403271
Abstract
Decisive for the development of chloroquine retinopathy is not the total cumulative dose. Recent findings indicate that retinopathy develops if daily dosages are too high. Therefore, daily dosages of 4 mg chloroquine/kg ideal body weight and 6.5 mg hydroxychloroquine/kg body weight, respectively, should not be exceeded. If these maximum daily dosages are observed, long-term therapy over periods of months or even years seems to be safe.
摘要
决定氯喹视网膜病变发展的并非总累积剂量。最近的研究结果表明，如果每日剂量过高，就会发生视网膜病变。因此，氯喹每日剂量不应超过4毫克/千克理想体重，羟氯喹每日剂量不应超过6.5毫克/千克体重。如果遵守这些每日最大剂量，数月甚至数年的长期治疗似乎是安全的。
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