Dr Phillip Frost Department of Dermatology and Miami Itch Center, University of Miami, Miami, FL, USA.
Derpartment of Dermatology, Verona University, Verona, Italy.
Exp Dermatol. 2021 Sep;30(9):1208-1217. doi: 10.1111/exd.14401. Epub 2021 Jun 5.
While there is a vast array of aetiologies that may lead to chronic pruritus, recent data suggests that many of these conditions share similar interactions between keratinocytes, nerves, and the immune system. Specifically, the type 2 immune response, including Th2 T Cells and their related cytokines, has been noted to play a major role in the development of pruritus in a variety of itchy conditions. To date, atopic dermatitis is the most striking example of this pathogenesis. However, the body of literature supporting its role in many other itchy conditions, including other inflammatory, bullous, as well as systemic diseases, continues to grow. In addition, new treatments targeting this type 2 immune system continue to be developed and investigated. In the current review, we present the current body of literature supporting the role of the type 2 immune response in itchy conditions beyond atopic dermatitis as well as potential therapeutic options that target this pathway for chronic itch.
虽然有大量的病因可能导致慢性瘙痒，但最近的数据表明，这些疾病中有许多在角质形成细胞、神经和免疫系统之间存在相似的相互作用。具体来说，2 型免疫反应，包括 Th2 T 细胞及其相关细胞因子，已被认为在多种瘙痒疾病的瘙痒发展中起主要作用。迄今为止，特应性皮炎是这种发病机制最明显的例子。然而，越来越多的文献支持其在许多其他瘙痒性疾病中的作用，包括其他炎症性、大疱性以及系统性疾病。此外，针对这种 2 型免疫系统的新治疗方法也在不断被开发和研究。在当前的综述中，我们介绍了支持 2 型免疫反应在特应性皮炎以外的瘙痒性疾病中的作用的现有文献，以及针对该通路治疗慢性瘙痒的潜在治疗选择。
