Chen Tsai-Ling, Chang Shu-Chen, Huang Chin-Yi, Wang Hsiu-Hung
College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Nursing, Changhua Christian Hospital, Changhua, Taiwan; College of Nursing and Health Sciences, Da-Yeh University, Changhua, Taiwan.
J Psychosom Res. 2021 Aug;147:110515. doi: 10.1016/j.jpsychores.2021.110515. Epub 2021 May 17.
Menopause is a normal physiological process experienced by women, but it is often accompanied by physical and emotional symptoms that may negatively affect quality of life. This meta-analysis aimed to evaluate the effectiveness of mindfulness-based interventions on quality of life and menopausal symptoms by examining randomized controlled trials.
A systematic search was conducted across six electronic databases to collect relevant articles published up to June 30, 2020. The articles' quality was assessed using the modified Jadad scale. We performed a meta-analysis with Review Manager 5.3, calculating 95% confidence intervals and standardized mean differences, and conducted sensitivity analyses.
The meta-analysis of five randomized controlled trials included 475 participants. The results indicated that the mindfulness-based intervention groups showed significant improvements in total quality of life and vasomotor and physical quality of life, compared to control groups (standardized mean differences range: from -0.48 to -0.68, all ps < 0.05). After the sensitivity analyses, evidence of heterogeneity remained. Insufficient data prevented conducting a meta-analysis with the sexual subscale of MENQOL or on vasomotor symptoms of menopause.
For menopausal women, mindfulness-based interventions may improve quality of life (except for psychological and sexual subscales). However, there is insufficient evidence to analyze whether such interventions can reduce vasomotor-related menopausal symptoms. Although heterogeneity should be carefully assessed, mindfulness-based interventions may be a novel approach for improving women's overall quality of life during menopause. However, further research is needed to verify these effects.
绝经是女性经历的正常生理过程，但常伴有可能对生活质量产生负面影响的身体和情绪症状。本荟萃分析旨在通过审查随机对照试验来评估基于正念的干预措施对生活质量和绝经症状的有效性。
在六个电子数据库中进行系统检索，以收集截至2020年6月30日发表的相关文章。使用改良的雅达量表评估文章质量。我们使用Review Manager 5.3进行荟萃分析，计算95%置信区间和标准化均值差，并进行敏感性分析。
五项随机对照试验的荟萃分析纳入了475名参与者。结果表明，与对照组相比，基于正念的干预组在总体生活质量、血管舒缩和身体生活质量方面有显著改善（标准化均值差范围：-0.48至-0.68，所有p<0.05）。敏感性分析后，异质性证据仍然存在。数据不足妨碍了对MENQOL性分量表或绝经血管舒缩症状进行荟萃分析。
对于绝经后女性，基于正念的干预措施可能会改善生活质量（心理和性分量表除外）。然而，没有足够的证据分析此类干预措施是否能减轻与血管舒缩相关的绝经症状。尽管应仔细评估异质性，但基于正念的干预措施可能是改善绝经期间女性总体生活质量的一种新方法。然而，需要进一步研究来验证这些效果。
