Department of Neurosurgery, Fırat University, Elazığ, Turkey.
Department of Neurosurgery, Koc University Hospital, Istanbul, Turkey.
Pediatr Neurosurg. 2021;56(4):357-360. doi: 10.1159/000516379. Epub 2021 May 25.
Hydrocephalus is a common comorbidity among the newborns, with myelomeningocele (MMC) and ventriculoperitoneal (VP) shunts being frequently used for the treatment of such patients. In this study, we aimed to compare the effectiveness of antibiotic-free and antibiotic-coated shunts to reduce the rate of shunt infection in patients with hydrocephalus and accompanying MMC.
116 patients with hydrocephalus and MMC who were treated with VP shunts were included in the study. Shunt infection rates among antibiotic-free and antibiotic-coated shunts were compared.
Of the 116 patients included in the study, 39 had antibiotic-coated shunts and 77 had antibiotic-free shunts. Shunt infection developed in 4 of the 39 cases treated with antibiotic-coated shunts and in 5 of the 77 cases treated with shunts without antibiotics. No significant statistical difference was found between antibiotic-coated and antibiotic-free VP shunts in terms of shunt infection (p = 0.450, p > 0.05).
In patients with MMC, using VP shunts containing antibiotics was found not to have a protective effect in preventing shunt infection. Whether the sac is intact or ruptured does not affect this result.
脑积水是新生儿常见的合并症，常采用脊髓脊膜膨出（MMC）和脑室腹腔（VP）分流术治疗此类患者。本研究旨在比较无抗生素和抗生素涂层分流管在降低伴有 MMC 的脑积水患者分流感染率方面的效果。
本研究纳入了 116 例采用 VP 分流术治疗的脑积水伴 MMC 患者。比较了无抗生素和抗生素涂层分流管的分流感染率。
在纳入的 116 例患者中，39 例使用了抗生素涂层分流管，77 例使用了无抗生素的分流管。在使用抗生素涂层分流管的 39 例中，有 4 例发生了分流感染，在使用无抗生素的分流管的 77 例中，有 5 例发生了分流感染。抗生素涂层和无抗生素 VP 分流管在发生分流感染方面无显著统计学差异（p = 0.450，p > 0.05）。
在伴有 MMC 的患者中，使用含有抗生素的 VP 分流管并不能起到预防分流感染的保护作用。无论囊膜是否完整或破裂，都不会影响这一结果。
